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Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (518 reviews)

Staff was amazing, super clean

Reviewed on 2025/11/26

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (572 reviews)

The lady at the front was very kind and quick, which was nice because we were tired. Hottub was great and my son enjoyed the pool even though the heater was out. We definitely would stay again.

Reviewed on 2025/11/30

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.4/10 Exceptional! (216 reviews)

Fireplace was a nice surprise. Love that they had a ceiling fan. Staff was friendly and helpful.

Reviewed on 2025/11/18

See all 618 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.