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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (493 reviews)

Great history, great service, worth more than what was paid.

Reviewed on 2026/3/8

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,002 reviews)

Couples like: full-service spa, bar

Travelers say...

Absolutely beautiful! Our suite was huge and beautiful! Staff was friendly and superbly efficient. Location could not have been better for our stay. We will definitely be back!

Reviewed on 2026/3/6

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (730 reviews)

The staff was exceptional in welcoming our group, very informative of the hotel layout. Pool, hot tub and sauna all great. The morning staff was aware of outside conditions and gave safety advice. The breakfast was delish, great way for a send off! Would highly recommend staying here.

Reviewed on 2026/3/5

See all 1,207 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.