Photo by Visit Greenville, South Carolina

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Top Mountain Upstate South Carolina Hotels

Drury Inn & Suites Greenville

10 Carolina Point Pkwy, Greenville, SC

2 hours drive from Clemson University

Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.4/10 Exceptional! (1,007 reviews)

The staff were all extremely friendly and helpful. It is very nice having the option for a free dinner and breakfast. The rooms are definitely dated and my room was so loud. This hotel is right off an interstate and busy main road so the road noise is constant 24 hours a day. The walls are thin, ...

Reviewed on 2025/10/26

The Westin Poinsett Greenville

120 South Main St, Greenville, SC

1 hour drive from Clemson University

Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...

9.2/10 Wonderful! (1,008 reviews)

Can’t say enough good things about the perfect location, ambiance, and staff at this lovely hotel…a sophisticated treat iced with a warm & cozy glaze.

Reviewed on 2025/10/30

Hampton Inn Gaffney

115 Nancy Creek Rd, Gaffney, SC

3 hours drive from Clemson University

Stay at this hotel in Gaffney. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Gaffney ...

8.6/10 Excellent! (653 reviews)

The room was very clean and nice and warm.

Reviewed on 2025/10/26

See all 2,872 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.