Southeast Minnesota Luxury Vacations 2026

Photo by Sara Crotts

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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,263 reviews)

"The location could not be better."

Reviewed on 2026/8/15

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

8/10 Very Good! (1,006 reviews)

"The room was clean, large, and well maintained."

Reviewed on 2026/8/16

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.2/10 Very Good! (683 reviews)

"Friendly staff, easy check and breakfast was simple but fine. Hallway carpet should be changed, maybe figure out a way to reduce dampness in the air in the room. Room itself was clean."

Reviewed on 2026/8/13

See all 924 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.