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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...

9.8/10 Exceptional! (1,003 reviews)

This place was excellent from the check in, to the room, food, and you just can’t beat the view! Access to the park before opening hours is absolutely also worth every penny. I would recommend this hotel to anyone wanting to stay at the falls,

Reviewed on 2025/12/10

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Pamper yourself with a luxury stay at Iguazu Grand Resort Spa & Casino, where you can enjoy amenities like Champagne service, massage services, and more. The ...

9/10 Wonderful! (586 reviews)

This is a really wonderful hotel. Before my arrival the lovely concierge texted me to make sure they were prepared for my stay and graciously answered all my questions. I was given a wonderful room that faced their gorgeous pool area. The service at the hotel is flawless from the front desk, concierge ...

Reviewed on 2025/12/12

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Go for a luxurious stay at Gran Melia Iguazú, where you can enjoy amenities like massage services, Egyptian cotton sheets, and more. Deluxe amenities at this ...

9.2/10 Wonderful! (1,000 reviews)

Great stay with a great view!

Reviewed on 2025/12/10

See all 491 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.