Southeast Missouri Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
Top Luxury Southeast Missouri Hotels
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
- 3 hours drive from Mark Twain National Forest
Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
- 3 hours drive from Mark Twain National Forest
Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.
8/10 Very Good! (1,001 reviews)
"Definitely worth it, clean"
Reviewed on 2026/9/25
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
- 4 hours drive from Mark Twain National Forest
Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.