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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Pamper yourself with an extravagant stay at The Umstead Hotel and Spa, where you'll find deep soaking bathtubs and pillowtop beds. The spa, outdoor pool, and ...

9.6/10 Exceptional! (796 reviews)

"One the top hotels in the world"

Reviewed on 2026/7/16

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Go for a luxurious stay at The Carolina Inn, a Destination by Hyatt Hotel, where you can enjoy amenities like pillowtop beds, premium channels, and more. Notable ...

9.6/10 Exceptional! (1,000 reviews)

"The was the most beautiful hotel! Best location, hospitable staff and delicious food. They even had a laundry washer and dryer for us to use on floor 2. Would stay there again for sure!"

Reviewed on 2026/7/12

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

The Mayton is one of the Cary luxury 4-star boutique properties where you can pamper yourself with Champagne service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (772 reviews)

"historic buildings look great but do not function well in the heat of summer. The AC in the room never got below 73 degrees and was very warm."

Reviewed on 2026/7/15

See all 4,955 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.