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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Pamper yourself with an extravagant stay at The Umstead Hotel and Spa, where you'll find deep soaking bathtubs and pillowtop beds. The spa, outdoor pool, and ...

9.6/10 Exceptional! (781 reviews)

"The experience was just amazing. From welcome truffles made in house and spring water waiting for us in our room to the cozy robes and amazing room service."

Reviewed on 2026/6/13

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Go for a luxurious stay at The Carolina Inn, a Destination by Hyatt Hotel, where you can enjoy amenities like pillowtop beds, premium channels, and more. Notable ...

9.6/10 Exceptional! (1,002 reviews)

"Nice nice"

Reviewed on 2026/6/4

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

The Mayton is one of the Cary luxury 4-star boutique properties where you can pamper yourself with Champagne service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (764 reviews)

"Absolutely love this property! Great staycation spot."

Reviewed on 2026/6/11

See all 4,935 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.