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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (499 reviews)

Highly curated experience. Lean into it and let go. The pace is slow and contemplative on purpose. Ideal if you need to catch up on writing or reading. Loved it.

Reviewed on 2026/5/4

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.4/10 Very Good! (208 reviews)

Dan, the manager was so friendly and accommodating!

Reviewed on 2026/5/4

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,004 reviews)

Our sink didn't drain The shower didn't drain but the stopper didn't work, the cold water kept coming out of shower, so it didn't work to shower or take a bath

Reviewed on 2026/5/2

See all 946 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.