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Top Fishing Eastern South Dakota Hotels

Lewis and Clark Resort

43496 Shore Drive Yankton SD

2 hours drive from Denny Sanford Premier Center

Book a stay at this beach hotel in Yankton. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway ...

8.8/10 Excellent! (288 reviews)

Clean, full kitchen

Reviewed on 2025/12/25

Comfort Inn Yankton SD

611 W 23rd Street Yankton SD

2 hours drive from Denny Sanford Premier Center

Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (687 reviews)

It was good

Reviewed on 2026/1/16

See all 951 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.