Find Luxury Hotels in Uptown, FL

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Check availability on Uptown Luxury Hotels

Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 3 - Oct 5
In two weeks
Oct 10 - Oct 12

Top Uptown Luxury Hotels

Top Uptown Hotel Reviews

Southern Oaks Inn

Southern Oaks Inn

10/10 Excellent
"Warm welcome, clean and comfy stay, great location for a great price!"
Meredith 1-night trip
Posted 1 day ago
Southern Oaks Inn

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your Uptown vacation?
Use Expedia to arrange your flight to St. Augustine, FL (UST-Northeast Florida Regional) airport or Jacksonville International Airport (JAX) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to find what you want to make your stay special. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Uptown has to offer. Uptown has some interesting things to see and do including Ponce de Leon's Fountain of Youth Archaeological Park and Mission of Nombre de Dios, so you might want to take in the local sights during your visit.
What's there to see and do in Uptown?
When you're in Uptown, enjoy exploring the sights and attractions here including Ponce de Leon's Fountain of Youth Archaeological Park, Mission of Nombre de Dios, and Old Jail Museum. If you have a little extra time during your trip, you might want to make a stop at Matanzas River and Limelight Theatre.