La Quinta Inn & Suites Southern Illinois Hotels

A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Our top choices for Southern Illinois La Quinta Inn & Suites

A multi-story hotel with a covered entrance, stone pillars, and a parking lot.

A lobby with seating, a reception desk, and a snack area.

A hotel room with a bed, desk, chair, TV, and a minibar.

A counter with a coffee machine, condiment dispensers, and a display case with pastries.

1. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

Eastport

Taylor

NT$2,709

NT$3,114 total

includes taxes & fees

Sep 20 - Sep 21

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

An indoor swimming pool with lounge chairs and a clear view of the pool area.

A hotel room with a large bed, a desk with a chair, a flat-screen TV, a bathtub, and framed pictures on the wall.

2. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

NT$3,620

NT$4,054 total

includes taxes & fees

Sep 20 - Sep 21

A breakfast bar with a coffee machine, a cereal dispenser, and a fruit display.

A hotel entrance with a sign reading "La Quinta Inn & Suites".

Two HP desktop computers with keyboards and mice on a granite countertop.

A hotel room with two beds, a desk, a chair, and a window with curtains.

3. La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

O'Fallon

Tahjae

NT$2,278

NT$2,619 total

includes taxes & fees

Sep 17 - Sep 18

A lobby with a blue sofa, patterned cushions, a reception desk, and a mural of a moon and arch.

A breakfast bar with a microwave, coffee makers, and a fruit display.

A hotel room with a bed, a sofa, a desk, and a television.

A hotel with a central entrance, multiple floors, and a clear sky.

4. La Quinta Inn & Suites by Wyndham Pontoon Beach

Granite City

Weldon

NT$3,439

NT$3,954 total

includes taxes & fees

Sep 17 - Sep 18

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Top Southern Illinois Hotel Reviews

Super 8 by Wyndham Mt. Vernon IL

10/10 Excellent

"The room was excellent! We had a wonderful night's sleep and refreshed for the next day. Breakfast had everything our family needed to get started for the day. The man at the front desk was really friendly and helpful!"

Baymont by Wyndham Effingham

10/10 Excellent

"Room was clean. Staff was very friendly. Parking was easy."

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Great staff"

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"As a diehard Drury member, I stay at this location frequently to visit family in Illinois. I m never disappointed by a Drury Inn, I only wish I could sell my house and live there!"

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent

"Very comfy bed, TV lots of channels to surf and a tasty breakfast!"

Comfort Inn Edwardsville - St. Louis

10/10 Excellent

"A very nice place to stay. Breakfast was amazing."

Comfort Suites Fairview Heights - St. Louis

8/10 Good

"There was a smell in our room that was very strong. Other than that it was clean."

Comfort Suites Mount Vernon

8/10 Good

"Mmm"

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent

"We stayed one night, because it was right off the interstate. On our way to our final destination. Rooms were clean property was clean. There’s a lot of places to grab a bite to eat and Walmart is across the street. If you need other stuff. Felt very safe."

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La Quinta Inn & Suites Southern Illinois hotels

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southern Illinois La Quinta Inn & Suites

1. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

2. La Quinta Inn & Suites by Wyndham Effingham

3. La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

4. La Quinta Inn & Suites by Wyndham Pontoon Beach

Top Southern Illinois Hotel Reviews

Super 8 by Wyndham Mt. Vernon IL

Baymont by Wyndham Effingham

Drury Plaza Hotel Mt. Vernon

Drury Inn & Suites St. Louis O'Fallon, IL

Country Inn & Suites by Radisson, Effingham, IL

Comfort Inn Edwardsville - St. Louis

Comfort Suites Fairview Heights - St. Louis

Comfort Suites Mount Vernon

Quality Inn O'Fallon - St. Louis - Shiloh

Explore a world of travel with Expedia