What is Southampton like?

Travelers will be sure to enjoy their time in Houston's Southampton neighborhood.

If I need to cancel my hotel reservation in Southampton, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the "fully refundable" filter to review the best deals available in Southampton.

Where can I learn more about changing or cancelling my trip to Southampton?

For more information about picking new dates or cancelling your trip to Southampton, click here .

What can I see and do in this Houston neighborhood?

A few places to visit in the area around Southampton include Reliant Stadium, Twilight Epiphany Skyspace, and Rice Stadium. When you're sightseeing in Houston, Anderson Clarke Center and Main Street Theater - Rice Village are also worth a stop.

Top Southampton Hotels

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southampton hotels

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

1. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

4.4 km from Southampton

Elisa

NT$4,135 total

includes taxes & fees

Oct 18 - Oct 19

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

2. Hyatt Place Houston Medical Center

Texas Medical Center, 3 km from Southampton

Anthony

NT$4,744 total

includes taxes & fees

Oct 26 - Oct 27

A rooftop pool area with lounge chairs and a view of a tall building at night.

3. The Westin Houston Medical Center/Museum District

Texas Medical Center, 1.6 km from Southampton

Matthew

NT$6,384 total

includes taxes & fees

Oct 25 - Oct 26

A spacious living area with a dining table, chairs, and a chandelier.

4. Hotel Zaza Houston Museum District

2 km from Southampton

Madiha

NT$11,280 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

5. The Royal Sonesta Houston Galleria

The Galleria, 5.3 km from Southampton

Thomas

NT$5,275 total

includes taxes & fees

Oct 18 - Oct 19

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

6. Hilton Houston Plaza/Medical Center

Texas Medical Center, 1.5 km from Southampton

Marvin

NT$4,133 total

includes taxes & fees

Oct 18 - Oct 19

A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

7. The Chifley Houston, Tapestry Collection by Hilton

The Galleria, 5.2 km from Southampton

Silas

NT$5,176 total

includes taxes & fees

Oct 30 - Oct 31

A hotel lobby with a hot tub, a pool, and a dining area.

8. Drury Inn & Suites Houston Near the Galleria

The Galleria, 5.4 km from Southampton

Andrei

NT$4,146 total

includes taxes & fees

Oct 18 - Oct 19

9. Hyatt House Houston Medical Center

Texas Medical Center, 3 km from Southampton

Debra

NT$4,744 total

includes taxes & fees

Oct 29 - Oct 30

A person sitting on a white lounge chair with a striped towel, reading a book.

10. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

1.5 km from Southampton

Dustin

NT$2,503 total

includes taxes & fees

Nov 9 - Nov 10

A rooftop pool area with a covered seating area, a pool with a metal railing, and a cityscape view in the background.

11. Holiday Inn Express Houston - Galleria Area by IHG

The Galleria, 5 km from Southampton

Kaylyn

NT$4,893 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a sofa, ottoman, desk, and a bed.

12. Hyatt Place Houston/Galleria

5.9 km from Southampton

Saousan

NT$4,279 total

includes taxes & fees

Nov 1 - Nov 2

A restaurant with multiple dining tables, chairs, and a large chandelier.

13. Embassy Suites by Hilton Houston Downtown Convention Center

5.8 km from Southampton

darren

NT$6,001 total

includes taxes & fees

Oct 18 - Oct 19

A rooftop pool area with lounge chairs, a fire feature, and a neon sign for "RANCH WATER".

14. Hyatt Regency Houston/Galleria

5.8 km from Southampton

Diego

NT$5,864 total

includes taxes & fees

Nov 7 - Nov 8

A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

15. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

6 km from Southampton

Nerissa

NT$4,904 total

includes taxes & fees

Oct 22 - Oct 23

A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

16. Home2 Suites by Hilton at the Galleria

Greater Uptown, 5.6 km from Southampton

Alexis

NT$3,951 total

includes taxes & fees

Oct 18 - Oct 19

A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

17. Courtyard By Marriott Houston Medical Center Reliant Park

2.9 km from Southampton

Jorge

NT$4,381 total

includes taxes & fees

Nov 8 - Nov 9

A vending area with snacks, drinks, and a 'Fuel-Up Here' refrigerator.

18. Hampton Inn Houston-Near The Galleria

The Galleria, 5.2 km from Southampton

DAVIS

NT$3,807 total

includes taxes & fees

Oct 30 - Oct 31

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

19. Comfort Suites Houston near Medical Center- NRG Stadium

3.7 km from Southampton

Tamy

NT$2,988 total

includes taxes & fees

Nov 2 - Nov 3

A modern cityscape with high-rise buildings, including a curved skyscraper with illuminated windows and a rectangular building with a grid-like facade.

20. The Whitehall Houston

Houston Central Business District, 5 km from Southampton

Abraham

NT$4,916 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Where to stay in Southampton

Find the best Southampton areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

See properties

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

See properties

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

See properties

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

See properties

A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

See properties

Top Southampton Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

10/10 Excellent

"Blossom Hotel was an incredible experience — 5/5 stars! ⭐⭐⭐⭐⭐ The amenities are exceptional, and I would consider this hotel a minimum of 4 stars, although our stay truly felt like a 5-star experience! One of my favorite features was the complimentary laundry facility. You simply head downstairs to pick up free detergent pods, and there’s even a microwave available in the same area. The gym is also impressive, featuring Peloton bikes, with complimentary fruit and water available for guests. The rooms are incredibly spacious, and daily housekeeping keeps everything fresh and comfortable throughout your stay. Overall, Blossom Hotel exceeded our expectations. From the thoughtful amenities to the spacious rooms and excellent service, it was a fantastic stay. I would absolutely recommend it and would happily stay here again!"

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

10/10 Excellent

"The staff was very friendly and helpful! The property is in an ideal location, conveniently close to shopping and restaurants. The room was very spacious, and the balcony offered a beautiful view. I had a wonderful stay and will definitely be staying here again!"

The Chifley Houston, Tapestry Collection by Hilton

10/10 Excellent

"10/10 highly recommend! Our room was ready earlier than expected. The location is sooooo perfect, within walking distance of numerous restaurants and shopping areas. No need for an uber unless you’ve gotten your steps in for the day. The property was super well maintained and clean. I would definitely go back and recommend to family and friends."

Find hotels in Southampton, Houston

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southampton hotels

1. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

2. Hyatt Place Houston Medical Center

3. The Westin Houston Medical Center/Museum District

4. Hotel Zaza Houston Museum District

5. The Royal Sonesta Houston Galleria

6. Hilton Houston Plaza/Medical Center

7. The Chifley Houston, Tapestry Collection by Hilton

8. Drury Inn & Suites Houston Near the Galleria

9. Hyatt House Houston Medical Center

10. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

11. Holiday Inn Express Houston - Galleria Area by IHG

12. Hyatt Place Houston/Galleria

13. Embassy Suites by Hilton Houston Downtown Convention Center

14. Hyatt Regency Houston/Galleria

15. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

16. Home2 Suites by Hilton at the Galleria

17. Courtyard By Marriott Houston Medical Center Reliant Park

18. Hampton Inn Houston-Near The Galleria

19. Comfort Suites Houston near Medical Center- NRG Stadium

20. The Whitehall Houston

Where to stay in Southampton

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top Southampton Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

Frequently asked questions

Explore a world of travel with Expedia