Find Resorts & Hotels with Spas in Santee, SC

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Santee Resorts & Hotels with Spas

Tonight
Oct 8 - Oct 9
Tomorrow
Oct 9 - Oct 10
This weekend
Oct 10 - Oct 12
Next weekend
Oct 17 - Oct 19

Top Santee Resorts & Hotels with Spas

We don't have any properties that match your exact search
See all properties in Santee

Recommended hotels in Santee

Baymont by Wyndham Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1351)
"A nice location, plenty of parking, nice that breakfast was included. "
The price is NT$2,439
NT$2,708 total
includes taxes & fees
Oct 19 - Oct 20
Baymont by Wyndham Santee
Tru By Hilton Santee
Lobby

Tru By Hilton Santee

2.5 star property
9.2 out of 10, Wonderful, (556)
"Great stay"
The price is NT$3,324
NT$3,690 total
includes taxes & fees
Nov 3 - Nov 4
Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Property amenity

Fairfield Inn & Suites by Marriott Santee

2.5 star property
9.8 out of 10, Exceptional, (1003)
"Great stay for a quick weekend getaway!"
The price is NT$4,087
NT$4,536 total
includes taxes & fees
Nov 2 - Nov 3
Fairfield Inn & Suites by Marriott Santee
Best Western Plus Santee Inn
Exterior

Best Western Plus Santee Inn

2.5 star property
8.8 out of 10, Excellent, (1001)
"We really enjoyed our stay and will be back!"
The price is NT$4,148
NT$4,604 total
includes taxes & fees
Oct 19 - Oct 20
Best Western Plus Santee Inn
Hampton Inn Santee-I-95
Seasonal outdoor pool

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (1001)
"Staff was very friendly and accommodating. "
The price is NT$3,752
NT$4,164 total
includes taxes & fees
Nov 2 - Nov 3
Hampton Inn Santee-I-95
Travelodge by Wyndham Santee
Exterior

Travelodge by Wyndham Santee

2.0 star property
7.0 out of 10, Good, (661)
"Good location "
The price is NT$1,891
NT$2,099 total
includes taxes & fees
Oct 12 - Oct 13
Travelodge by Wyndham Santee
Holiday Inn Santee by IHG
Exterior

Holiday Inn Santee by IHG

3.0 star property
8.2 out of 10, Very Good, (951)
"Friendly and helpful staff. Overall a very good stay."
The price is NT$3,391
NT$3,764 total
includes taxes & fees
Oct 19 - Oct 20
Holiday Inn Santee by IHG
Ramada by Wyndham Santee I-95
Property amenity

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (537)
"The grounds and property were clean and you could tell they take pride in what they're offering."
The price is NT$2,176
NT$2,415 total
includes taxes & fees
Nov 2 - Nov 3
Ramada by Wyndham Santee I-95
Quality Inn & Suites
Business center

Quality Inn & Suites

2.5 star property
6.0 out of 10, (442)
"Entire place was filthy I did not even check in "
The price is NT$1,918
NT$2,298 total
includes taxes & fees
Oct 19 - Oct 20
Quality Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santee Hotel Reviews

Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

10/10 Excellent
"Clean room, staff was welcoming "
Niya 1-night trip
Posted 4 days ago
Spark by Hilton Orangeburg

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Santee?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Travelers recommend the gourmet restaurants in Santee. Be sure to enjoy activities like fishing and golfing during your stay. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Santee?
Enjoy all that Santee has to offer when you visit Santee Cooper Country Club, Santee National Golf Club, and Santee State Park. If you have a bit of extra time while you're in the area, you might want to check out Lake Marion and Santee Town Hall.
What is a Santee spa hotel?
Spa hotels in Santee provide lodging and have an on-site spa offering services such as facials and beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.