Find Luxury Hotels in Santee, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Luxury Hotels

Tonight
Dec 20 - Dec 21
Tomorrow
Dec 21 - Dec 22
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

Free breakfast
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1003)
"Rooms are clean, friendly staff and easy to get off and back on the highway. "
United States
Michelle
The price is NT$4,239
NT$4,706 total
includes taxes & fees
Jan 18 - 2026/1/19
Hampton Inn Santee-I-95
Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1002)
"Staff very friendly, room super clean"
United States
Karine
The price is NT$3,816
NT$4,236 total
includes taxes & fees
Jan 20 - 2026/1/21
Fairfield Inn & Suites by Marriott Santee
Free daily buffet breakfast
Tru By Hilton Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (644)
"Nice place to stay"
Canada
Tanya
The price is NT$3,314
NT$3,679 total
includes taxes & fees
Jan 4 - 2026/1/5
Tru By Hilton Santee
Exterior
Best Western Plus Santee Inn

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1001)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is NT$3,729
NT$4,139 total
includes taxes & fees
Dec 28 - Dec 29
Best Western Plus Santee Inn
Exterior
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very Good, (975)
"Was able to walk to convenience store and other dinning alternatives. Safe secure building"
United States
Joan
The price is NT$3,156
NT$3,503 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Santee by IHG
Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1001)
"Staff was pleasant and helpful with restaurant information, room clean. "
United States
Mark
The price is NT$3,238
NT$3,594 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1418)
"Very friendly staff. "
United States
Ramil
The price is NT$2,523
NT$2,800 total
includes taxes & fees
Jan 20 - 2026/1/21
Baymont by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
"Very friendly staff. Room was clean."
Barbara 1-night trip
Posted 1 day ago
Baymont by Wyndham Santee

Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia Metropolitan Airport (CAE) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee State Park, and Lake Marion. If you have a little extra time during your trip, you might want to make a stop at Santee National Golf Club and Santee Town Hall.

Explore a world of travel with Expedia