An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Find Luxury Hotels in Santee, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Luxury Hotels

Tonight
Oct 13 - Oct 14
Tomorrow
Oct 14 - Oct 15
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

A patio area with wicker furniture, a stone fire pit, and outdoor seating.
A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.
A reception desk with a wooden panel wall and a circular decorative piece above it.
A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

1. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
Santee
NT$4,425
NT$4,911 total
includes taxes & fees
Oct 19 - Oct 20
Fairfield Inn & Suites by Marriott Santee
A hotel entrance with a sign reading "Best Western PLISS."
A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

2. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
NT$4,437
NT$4,926 total
includes taxes & fees
Oct 14 - Oct 15
Best Western Plus Santee Inn
A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.
A gym with treadmills, weight machines, and a wall of dumbbells.
A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.
A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

3. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
Santee
NT$3,762
NT$4,176 total
includes taxes & fees
Nov 2 - Nov 3
Hampton Inn Santee-I-95
A breakfast area with a self-service counter, refrigerated display, and a digital menu board.
A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."
A modern lobby with a blue sofa, teal chairs, and a wooden table.
A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

4. Tru By Hilton Santee

Tru By Hilton Santee
Santee
NT$3,229
NT$3,584 total
includes taxes & fees
Nov 1 - Nov 2
Tru By Hilton Santee
A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.
A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.
A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.
A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

5. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
Santee
  • Remodeled Santee getaway features Italian linens, pillowtop beds, and outdoor pool in entertainment district.
NT$3,301
NT$3,664 total
includes taxes & fees
Nov 8 - Nov 9
Comfort Inn & Suites Santee
A water park with a pool, slides, and umbrellas.
A reception desk with a wooden panel backdrop and a neon sign.
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A modern lounge area with seating, tables, and a fireplace.

6. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
Santee
NT$3,224
NT$3,579 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Santee by IHG
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.
A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

7. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
  • Santee sanctuary offers premium comfort, concierge service, daily breakfasts, and central access to attractions.
NT$2,554
NT$2,835 total
includes taxes & fees
Oct 14 - Oct 15
Baymont by Wyndham Santee
Lobby
A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.
A gym with treadmills, an elliptical, dumbbells, and a bench.
A conference room with round tables, black chairs, and white tablecloths.

8. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
  • Luxurious golf retreat with plush Egyptian cotton bedding and poolside cocktails along Santee's scenic fairways.
NT$2,500
NT$2,775 total
includes taxes & fees
Oct 14 - Oct 15
Ramada by Wyndham Santee I-95
A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.
A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.
A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.
A kitchen with a countertop, cabinets, a microwave, and a sink.

9. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
Santee
NT$2,043
NT$2,268 total
includes taxes & fees
Oct 21 - Oct 22
Travelodge by Wyndham Santee
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.
A two-story building with a beige facade, large windows, and a central entrance.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

10. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
NT$2,035
NT$2,259 total
includes taxes & fees
Oct 21 - Oct 22
Super 8 by Wyndham Santee/I-95
View all properties

Top Santee Hotel Reviews

Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg

8/10 Good
"Hotel is dated however it is perfect for an overnight traveler. Internet was intermittent at best."
Chris 1-night trip
Posted 4 hours ago
Travelodge by Wyndham Orangeburg
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

10/10 Excellent
"I like everything. And when I went to get coffee the lady cleaning in there was so nice."
Latonya 1-night trip
Posted 23 hours ago
SureStay Hotel by Best Western Manning
Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
":)"
Robert 1-night trip
Posted 2 days ago
Baymont by Wyndham Santee
Red Roof Inn Santee

Red Roof Inn Santee

10/10 Excellent
"Nice place. Clean & mattress was super comfy!"
Karyn 1-night trip
Posted 1 month ago
Red Roof Inn Santee

Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia Metropolitan Airport (CAE) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee State Park, and Lake Marion. If you have a little extra time during your trip, you might want to make a stop at Santee National Golf Club and Santee Town Hall.

Explore a world of travel with Expedia