Find Luxury Hotels in Santee, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Luxury Hotels

Tonight
Nov 28 - Nov 29
Tomorrow
Nov 29 - Nov 30
This weekend
Nov 28 - Nov 30
Next weekend
Dec 5 - Dec 7

Top Santee Luxury Hotels

Lobby
Red Roof Inn Santee

Red Roof Inn Santee

2.0 star property
Santee
  • Breakfast included
  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
  • Housekeeping
6.6 out of 10, (635)
Premium channels illuminate flat-screen TVs while laptop-friendly workspaces enhance productivity in air-conditioned sanctuaries. Morning rituals begin with complimentary breakfast before exploring nearby Santee Cooper Country Club, just minutes from this peaceful retreat.
The price is NT$2,194
NT$2,435 total
includes taxes & fees
Nov 30 - Dec 1
Red Roof Inn Santee
Lobby
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 star property
Santee
  • Pool
  • Breakfast included
  • Parking included
  • Free WiFi
  • Air conditioning
  • Gym
8.0 out of 10, Very Good, (1005)
Savor morning indulgence with a complimentary breakfast buffet at this recently renovated Santee retreat. Luxurious Frette Italian sheets and pillowtop beds promise restful nights, while a seasonal outdoor pool and fitness center provide daytime recreation just steps from local golf courses.
The price is NT$3,091
NT$3,431 total
includes taxes & fees
Dec 14 - Dec 15
Comfort Inn & Suites Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 star property
Santee
  • Concierge services
8.0 out of 10, Very Good, (1405)
Concierge services elevate stays at this centrally located Santee hotel where thoughtful luxury meets convenience. Spotlessly clean rooms provide peaceful retreats with premium entertainment channels. Staff members consistently deliver friendly, responsive service, ensuring every guest enjoys a sophisticated experience.
The price is NT$2,507
NT$2,783 total
includes taxes & fees
Nov 30 - Dec 1
Baymont by Wyndham Santee
Property amenity
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2.0 star property
Santee
  • 24-hour gym
  • Poolside bar
  • 18 holes of golf
6.2 out of 10, (540)
Sumptuous pillowtop beds dressed in Egyptian cotton welcome weary travelers at this golf-adjacent sanctuary. Sun-drenched days alternate between 18 holes of championship golf and refreshing dips in the outdoor pool, complete with craft cocktails from the poolside bar.
The price is NT$2,442
NT$2,710 total
includes taxes & fees
Dec 14 - Dec 15
Ramada by Wyndham Santee I-95
Exterior
Econo Lodge

Econo Lodge

2.0 star property
Santee
  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
  • 24/7 front desk
  • Microwave
6.4 out of 10, (309)
Sophisticated comfort awaits at this centrally located Santee hotel, just steps from Lake Marion. Spacious rooms boast 42-inch flat-screen TVs, while the serene garden provides a tranquil setting for afternoon barbecues after exploring nearby golf courses and parks.
The price is NT$1,966
NT$2,183 total
includes taxes & fees
Dec 24 - Dec 25
Econo Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
"Check in was great. Latoya was wonderful she saw that I was pulling a trailer and made sure to tell me where I could park that was near my room. She was the sweetest lady. The room was clean. No bugs (big one for me). And although right off I95 it was very quiet. The rooms face outside so parking in front of your room. "
Cindy 1-night trip
Posted 8 days ago
Baymont by Wyndham Santee

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia Metropolitan Airport (CAE) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee National Golf Club, and Santee State Park. If you have a little extra time during your trip, you might want to make a stop at Lake Marion and Santee Town Hall.