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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Nov 6 - Nov 8
In two months
Dec 18 - Dec 20
In three months
Jan 15 - Jan 17
In four months
Feb 12 - Feb 14

Our top choices for Santa Cruz vacation rentals

A modern hotel room with a large bed, a desk, a chair, a potted plant, and a view of the mountains.

1. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (141 reviews)
"Excellent Stay!"
United States
Esdras
The price is NT$1,561
NT$1,561 total
Oct 22 - Oct 23
Go Living and Suites by Jalo
A bedroom with a bed, a bedside table with a plant, a sofa, and a wall with a large blue arch.

2. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (5 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is NT$806
NT$806 total
Oct 22 - Oct 23
Hotel Moore 45
A modern living room with a large window, a sofa set, a coffee table, and a potted plant.

3. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (92 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is NT$1,616
NT$2,332 total
Oct 22 - Oct 23
Metropolitan Living by HOUSY
A neatly made bed with a wooden headboard, a bedside table with a bottle and a glass, and a chair in a bright room with a large window.

4. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (298 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is NT$2,626
NT$2,626 total
Nov 1 - Nov 2
Portal del Rodeo ApartaHotel - Arkadia Mall
A compact kitchen with a microwave, double sink, and built-in dishwasher.

5. ONCE SUITES

ONCE SUITES
3.0 star property
Envigado
10.0 out of 10, Exceptional, (3 reviews)
"Very close to everything"
United States
PAOLA
The price is NT$1,694
NT$1,694 total
Nov 4 - Nov 5
ONCE SUITES
A person relaxing in a hot tub with a scenic view of mountains and clouds.

6. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
The price is NT$1,935
NT$2,427 total
Nov 2 - Nov 3
Skyline Ecoliving
A modern restaurant with high ceilings, large windows, and a city view. Tables are set with dishes and drinks.

7. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
The price is NT$1,564
NT$1,564 total
Oct 22 - Oct 23
Edificio Helena
A woman standing by a balcony with a view of a rural landscape.

8. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
The price is NT$3,307
NT$3,307 total
Oct 26 - Oct 27
Travelers Rio Verde Living Suites
A rooftop patio with tables and chairs, a bar area, and a view of the cityscape.

9. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (26 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
The price is NT$1,753
NT$1,753 total
Oct 22 - Oct 23
B 48 Living by B Rent
An outdoor café with tables and chairs, surrounded by potted plants and a view of buildings.

10. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (106 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is NT$1,475
NT$1,475 total
Oct 25 - Oct 26
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
A modern apartment with a living area, kitchenette, and large windows offering city views.

11. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.0 out of 10, Wonderful, (201 reviews)
"Great place to stay at"
United States
Miguel
The price is NT$1,746
NT$1,746 total
Oct 22 - Oct 23
Kyux by Jalo
A modern living room with a white sofa, round coffee table, and a dining area with a wooden table and chairs.

12. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (461 reviews)
"Great location, secure place, quiet, private parking"
United States
CAMILO
The price is NT$1,495
NT$2,470 total
Nov 8 - Nov 9
Apartment Go Living & Suites by HOUSY HOST
A rooftop terrace with two hot tubs, a dining area with chairs and a table, and a view of a cityscape with mountains in the background.

13. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (117 reviews)
"Great hotel. Loved the views at the hot tub!"
United States
Maria Lucia
The price is NT$1,549
NT$1,549 total
Oct 26 - Oct 27
Quadrato Studios
A modern interior with marble flooring, a reception area, and a seating area with tables and chairs.

14. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (750 reviews)
"Service was amazing !!! Very nice hotel, room, rooftop lounge/pool"
Canada
Shyla
The price is NT$2,944
NT$2,944 total
Oct 28 - Oct 29
Haven, A Design Hotel
A modern living room with a large window, a sofa, a coffee table, and a kitchen area with a marble island.

15. Loft 43

Loft 43
3.0 star property
Laureles
8.6 out of 10, Excellent, (39 reviews)
"The staff was super accommodating and very helpful with the area and finding places near by for good food and activities."
United States
Alexis
The price is NT$1,889
NT$1,889 total
Nov 3 - Nov 4
Loft 43
A modern hotel room with a large bed, a flat-screen TV, and a view of the city through large windows.

16. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (146 reviews)
"Everything was great we will definitely be back Super clean, great location and everyone was wonderful"
United States
Michelle
The price is NT$2,677
NT$3,603 total
Oct 27 - Oct 28
Factory Lofts
A modern hotel room with a bed, bedside table, lamp, and a TV.

17. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (222 reviews)
"VERY CONVENIENT, CLOSE TO EVERYTHING AND SAFE."
United States
Rulph
The price is NT$1,893
NT$1,893 total
Nov 3 - Nov 4
Origen Local Suites
A bedroom with a bed, a TV mounted on the wall, a window with a view of trees, and a kitchenette area.

18. Amaranto Suites

Amaranto Suites
3.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (7 reviews)
"Perfect"
United States
Alexander
The price is NT$1,143
NT$1,143 total
Oct 23 - Oct 24
Amaranto Suites
A modern hotel room with a large bed, a TV mounted on the wall, and a view of the cityscape through large windows.

19. HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (112 reviews)
"The staff was helpfull"
United States
Elsje
The price is NT$1,564
NT$2,609 total
Oct 22 - Oct 23
HOUSY Laureles
A modern hotel room with a large bed, a small table, a potted plant, and a city view through the window.

20. Estelar Apartamentos Medellin

Estelar Apartamentos Medellin
3.5 star property
El Poblado
8.8 out of 10, Excellent, (501 reviews)
"Great location"
United States
Andrew
The price is NT$3,639
NT$3,639 total
Oct 25 - Oct 26
Estelar Apartamentos Medellin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

10/10 Excellent
"Great staff and rooms are very clean and tidy. Location is safe and walking distance to clubs and bars"
Tamzid 4-night trip
Posted 4 hours ago
Hashtag 98 Hotel By Jalo

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.