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Dec 10 - Dec 11
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Dec 11 - Dec 12
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Dec 12 - Dec 14
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Our top choices for Santa Clara hotels

47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1001)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
The price is NT$6,300
NT$6,930 total
includes taxes & fees
Dec 12 - Dec 13
Central Hotel Panama Casco Viejo
Front of property
La Concordia Boutique Hotel

La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (194)
"Beautiful room Good location"
United States
Karla
The price is NT$6,939
NT$7,633 total
includes taxes & fees
Dec 14 - Dec 15
La Concordia Boutique Hotel
Reception
Hotel Coral Suites

Hotel Coral Suites

Hotel Coral Suites
3.5 star property
Bella Vista
9.0 out of 10, Wonderful, (1005)
"Great place for the price. "
United States
Ryan
The price is NT$2,077
NT$2,284 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Coral Suites
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1003)
"I loved everything about my stay "
United States
Stephanie
The price is NT$5,600
NT$6,160 total
includes taxes & fees
Dec 16 - Dec 17
Waldorf Astoria Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1004)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is NT$5,461
NT$6,007 total
includes taxes & fees
Dec 19 - Dec 20
The Westin Playa Bonita Panama
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1848)
"Very nice hotel centered around courtyard and pool. Convenient for airport "
Canada
Miles
The price is NT$3,899
NT$4,289 total
includes taxes & fees
Dec 13 - Dec 14
Riande Aeropuerto Hotel & Casino
Exterior
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro
3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1007)
"Great staff and the room was very clean. "
United States
JOHNNY
The price is NT$2,847
NT$3,132 total
includes taxes & fees
Dec 16 - Dec 17
TRYP by Wyndham Panamá Centro
Aerial view
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

Gamboa Rainforest Reserve
3.5 star property
Colon
7.8 out of 10, Good, (662)
"Beautiful place to stay for one night. A little over priced for Panama but the service and the food were excellent. "
Canada
Dan
The price is NT$3,901
NT$4,291 total
includes taxes & fees
Dec 11 - Dec 12
Gamboa Rainforest Reserve
Exterior
Aloft Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco
8.8 out of 10, Excellent, (891)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is NT$3,648
NT$4,013 total
includes taxes & fees
Dec 16 - Dec 17
Aloft Panama
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1590)
"Great hotel, location, food. Highly recommend the sushi restaurant next door.. One of the best ever. "
United States
Lakshmin
The price is NT$1,559
NT$1,715 total
includes taxes & fees
Dec 27 - Dec 28
Principe Hotel and Suites
Front of property
Novotel Panama City

Novotel Panama City

Novotel Panama City
4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1017)
"Great service, big room, solid breakfasts.. all at good price."
Canada
Nicholas
The price is NT$3,312
NT$3,643 total
includes taxes & fees
Dec 13 - Dec 14
Novotel Panama City
Couples treatment rooms, sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is NT$6,150
NT$6,765 total
includes taxes & fees
Jan 9 - 2026/1/10
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is NT$7,226
NT$7,949 total
includes taxes & fees
Dec 12 - Dec 13
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (693)
"The breakfast was great, I love the pool."
United States
Estefani
The price is NT$1,605
NT$1,766 total
includes taxes & fees
Jan 5 - 2026/1/6
Hospedium Princess Hotel Panama
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1006)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is NT$3,154
NT$3,469 total
includes taxes & fees
Jan 5 - 2026/1/6
Courtyard by Marriott Panama Metromall
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is NT$9,992
NT$10,992 total
includes taxes & fees
Dec 14 - Dec 15
Hotel La Compañía Casco Antiguo
Outdoor pool, sun loungers
Hampton by Hilton Panama

Hampton by Hilton Panama

Hampton by Hilton Panama
3.0 star property
Bella Vista
7.8 out of 10, Good, (1000)
"The hotel is good for the price , the lobby didn’t have any air conditioning,also the rooms where clean but needed to be updated , the breakfast buffet had multiple choices and it was very good . The hotel is in great location near walking distance to restaurants and stores . I will stay again. "
United States
Yusneilys amores
The price is NT$2,245
NT$2,470 total
includes taxes & fees
Dec 19 - Dec 20
Hampton by Hilton Panama
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2138)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is NT$3,201
NT$3,521 total
includes taxes & fees
Dec 11 - Dec 12
Plaza Paitilla Inn Hotel
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very Good, (1261)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is NT$4,316
NT$4,747 total
includes taxes & fees
Jan 3 - 2026/1/4
Megapolis Hotel Panamá
Private kitchen
Mahogany Suites

Mahogany Suites

Mahogany Suites
2.0 star property
Rousseau
10.0 out of 10, Exceptional, (1)
"Todo ok"
Colombia
Juan
The price is NT$3,648
NT$4,013 total
includes taxes & fees
Dec 28 - Dec 29
Mahogany Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Clara attractions

Culebra Cut

You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.
See properties

Learn more about Santa Clara

Santa Clara awaits: its natural setting, monuments, history, and more!

See all hotels in Santa Clara
Adobe

Top Santa Clara Hotel Reviews

W Panama

W Panama

10/10 Excellent
"excellent "
Lyndell 4-night trip
Posted 2 days ago
W Panama

More cheap stays in Santa Clara

Viajero Casco Viejo Hostel

Viajero Casco Viejo Hostel

Avenida B, Calle 12 Este, Casco Viejo Panama City
The price is NT$2,130 per night from Dec 16 to Dec 17
NT$2,130
NT$2,515 total
Dec 16 - Dec 17
includes taxes & fees
7/10 Good! (10 reviews)

Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Megapolis Hotel Panamá. See all available top hotels, or vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1682 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.

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