Find hotels in Santa Clara from NT$1,433

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Dec 23 - Dec 24
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Dec 24 - Dec 25
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Dec 26 - Dec 28
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Our top choices for Santa Clara hotels

Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1855)
"The room was impeccable, staff was awesome and very professional!!!"
United States
Scott
The price is NT$3,944
NT$4,339 total
includes taxes & fees
Dec 24 - Dec 25
Riande Aeropuerto Hotel & Casino
Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4713)
"Awesome great place to stay "
United States
Herbert
The price is NT$3,449
NT$3,794 total
includes taxes & fees
Jan 12 - 2026/1/13
Hotel Riu Plaza Panama
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (643)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is NT$7,073
NT$7,781 total
includes taxes & fees
Jan 18 - 2026/1/19
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1002)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is NT$3,458
NT$3,804 total
includes taxes & fees
Jan 8 - 2026/1/9
Courtyard by Marriott Panama Metromall
Outdoor pool, pool umbrellas, sun loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1123)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
The price is NT$3,088
NT$3,397 total
includes taxes & fees
Jan 10 - 2026/1/11
Ramada Plaza by Wyndham Panama Punta Pacifica
2 outdoor pools, pool umbrellas, sun loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador
8.4 out of 10, Very Good, (1004)
"Wonderful staff and easy checkin!"
United States
Kristin
The price is NT$2,627
NT$2,890 total
includes taxes & fees
Jan 7 - 2026/1/8
Radisson Hotel Panama Canal
Terrace/patio
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (994)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is NT$4,230
NT$4,653 total
includes taxes & fees
Jan 9 - 2026/1/10
Sheraton Grand Panama
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (166)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is NT$2,334
NT$4,025 total
includes taxes & fees
Jan 3 - 2026/1/4
Arcadia Condo Suites
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (128)
"Great hotel fair price"
United States
Santiago
The price is NT$4,944
NT$5,438 total
includes taxes & fees
Jan 4 - 2026/1/5
Hyatt Regency Panama City
Exterior
Hotel Milan

Hotel Milan

Hotel Milan
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (430)
"It was a very pleasant experience the hotel is located in a great neighborhood, staff were friendly and competent, secure property and parking, clean and decent accommodations, especially at the room price point. "
Canada
Roger
The price is NT$1,262
NT$1,388 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Milan
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2140)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is NT$3,539
NT$3,893 total
includes taxes & fees
Jan 15 - 2026/1/16
Plaza Paitilla Inn Hotel
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1004)
"Great place and location, excellent food choices! "
United States
Francisco
The price is NT$7,189
NT$7,908 total
includes taxes & fees
Jan 8 - 2026/1/9
The Westin Playa Bonita Panama
Front of property
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel
3.5 star property
Amador
8.2 out of 10, Very Good, (193)
"Perfect location, nice rooms, nice views"
United States
Ever
The price is NT$3,690
NT$4,059 total
includes taxes & fees
Jan 2 - 2026/1/3
MARINN Tropical Vibes Hotel
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1613)
"Friendly staff. "
United States
Thessely
The price is NT$1,609
NT$1,769 total
includes taxes & fees
Dec 24 - Dec 25
Principe Hotel and Suites
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama
3.5 star property
Bella Vista
7.4 out of 10, Good, (710)
"The breakfast was great, I love the pool."
United States
Estefani
The price is NT$1,624
NT$1,786 total
includes taxes & fees
Jan 12 - 2026/1/13
Hospedium Princess Hotel Panama
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1006)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is NT$4,950
NT$5,445 total
includes taxes & fees
Jan 13 - 2026/1/14
Las Americas Golden Tower Panama
Lobby
The Executive Hotel

The Executive Hotel

The Executive Hotel
3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1004)
"A nice hotel to stay great location"
United States
angela
The Executive Hotel
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1459)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is NT$4,435
NT$4,879 total
includes taxes & fees
Jan 3 - 2026/1/4
Decapolis Hotel Panama City
4 outdoor pools, free cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1003)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is NT$10,062
NT$11,068 total
includes taxes & fees
Jan 3 - 2026/1/4
JW Marriott Panama
View from room
The Beach House

The Beach House

The Beach House
3.0 star property
Amador
8.4 out of 10, Very Good, (408)
"Fantastic location on Amador Causeway and access to paddleboarding, restaurants, nightlife and family friendly events. One cool sloth in the tree overhanging the walkway at the Culebra nature area right by the prroperty."
United States
Cynthia
The Beach House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Clara attractions

Culebra Cut

You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.
See properties

Learn more about Santa Clara

Santa Clara awaits: its natural setting, monuments, history, and more!

See all hotels in Santa Clara
Adobe

Top Santa Clara Hotel Reviews

Megapolis Hotel Panamá

Megapolis Hotel Panamá

10/10 Excellent
"Excellent check-in. Great breakfast. Room was great "
Reginald 5-night trip
Posted 3 days ago
Megapolis Hotel Panamá

More cheap stays in Santa Clara

Panama House Bed & Breakfast

Panama House Bed & Breakfast

Calle 1era El Carmen- Casa # 32 Panama City
The price is NT$1,303 per night from Dec 28 to Dec 29
NT$1,303
NT$1,433 total
Dec 28 - Dec 29
includes taxes & fees
8.8/10 Excellent! (185 reviews)

Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Megapolis Hotel Panamá. See all available top hotels, or vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1675 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.