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Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,171 reviews)
"Clean room, great restaurants in site."
United States
Michelle
The price is NT$5,912
NT$7,290 total
includes taxes & fees
Feb 1 - Feb 2
Lani Kai Beachfront Resort

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (225 reviews)
"Very clean very nice staff"
United States
Edward
The price is NT$1,408
NT$3,662 total
includes taxes & fees
Feb 6 - Feb 7
Matlacha on Shoreview

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.8 out of 10, Good, (1,000 reviews)
"Respectful staff will let everybody I know about this place it’s awesome "
United States
Carlos rivera
The price is NT$2,972
NT$3,314 total
includes taxes & fees
Feb 14 - Feb 15
Allure Suites

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Great stay"
United States
Andrea
The price is NT$8,306
NT$9,261 total
includes taxes & fees
Feb 14 - Feb 15
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,002 reviews)
"Staff was great!"
United States
Jeff
The price is NT$4,724
NT$5,267 total
includes taxes & fees
Jan 30 - Jan 31
Residence Inn by Marriott Fort Myers Sanibel

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1,000 reviews)
"Nice place with friendly staff. "
United States
Scott E.
The price is NT$5,005
NT$5,581 total
includes taxes & fees
Feb 1 - Feb 2
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (274 reviews)
"The property was super cute and clean! It also had just about anything you could need!"
United States
Wyatt
The price is NT$3,696
NT$6,467 total
includes taxes & fees
Feb 9 - Feb 10
Matlacha Tiny Village

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (933 reviews)
"Beautiful clean room friendly staff beautiful scenery"
United States
Cassie
Latitude 26 Waterfront Resort & Marina

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.4 out of 10, Very Good, (18 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is NT$2,503
NT$3,802 total
includes taxes & fees
Jan 30 - Jan 31
TriLuxe Inn & Studios

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,002 reviews)
"Very good 👍 "
United States
Verona
The price is NT$2,271
NT$2,751 total
includes taxes & fees
Jan 30 - Jan 31
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,010 reviews)
"Great stay"
United States
Erica
The price is NT$5,782
NT$6,447 total
includes taxes & fees
Feb 5 - Feb 6
Hilton Garden Inn Ft Myers

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Great stay "
United States
Brandon
The price is NT$5,526
NT$6,161 total
includes taxes & fees
Feb 1 - Feb 2
Doubletree by Hilton Fort Myers at Bell Tower Shops

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (240 reviews)
"Very nice. Great for a short or longer term stay."
United States
Finley
The price is NT$2,596
NT$3,907 total
includes taxes & fees
Jan 30 - Jan 31
Lazy Cuckoo Inn

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,570 reviews)
"Sweet staff, amazing beach access, pool, restaurant on site. Good value and great stay!"
United States
Freda
The price is NT$10,292
NT$12,258 total
includes taxes & fees
Feb 1 - Feb 2
Sanibel Island Beach Resort

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (814 reviews)
"Quiet, clean and accommodating staff."
United States
George
The price is NT$4,036
NT$4,500 total
includes taxes & fees
Feb 1 - Feb 2
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,192 reviews)
"Is great place to stay."
United States
Anastassia
The price is NT$4,505
NT$5,023 total
includes taxes & fees
Feb 1 - Feb 2
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1,608 reviews)
"Such a fun place to stay and the beds were comfortable! "
United States
Lauren
The Lighthouse Resort Inn & Suites

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is NT$4,633
NT$5,166 total
includes taxes & fees
Feb 8 - Feb 9
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,000 reviews)
"Amazing room and view. Great place to stay/vacation. Would come back over and over again. "
United States
Frank
The price is NT$7,208
NT$9,296 total
includes taxes & fees
Feb 8 - Feb 9
The Westin Cape Coral Resort At Marina Village

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.2 out of 10, Very Good, (50 reviews)
"Clean, easy access, quiet, best bed and sheets ever!!!"
United States
Brooke
The price is NT$2,503
NT$3,802 total
includes taxes & fees
Jan 30 - Jan 31
White Orchid Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 11 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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