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Dec 1 - Dec 2
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Dec 2 - Dec 3
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

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Discover Sanctuary hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

On the beach, white sand, kayaking, motor boating
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1015)
"This was thr best place that we have ever stayed at. "
United States
Matthew
The price is NT$5,577
NT$7,003 total
includes taxes & fees
Dec 14 - Dec 15
Marriott Sanibel Harbour Resort & Spa
Interior entrance
Allure Suites

Allure Suites

3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1012)
"Was clean staff was very nice"
United States
Richard J
Allure Suites
Deluxe Studio, 1 King Bed, Marina View | View from room
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1015)
"Great Place to Stay!"
United States
JUDY
The price is NT$3,087
NT$3,442 total
includes taxes & fees
Dec 2 - Dec 3
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Aerial view
DiamondHead Beach Resort

DiamondHead Beach Resort

3.5 star property
22.3 km from Sanctuary
9.0 out of 10, Wonderful, (1013)
"Very clean, super nice staff and the room was more than we expected."
United States
Toni
DiamondHead Beach Resort
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1012)
"Clean room, wonderful staff, and nice breakfast. "
United States
Danielle
The price is NT$2,982
NT$3,325 total
includes taxes & fees
Dec 2 - Dec 3
Residence Inn by Marriott Fort Myers Sanibel
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1028)
"Excellent room and price! Breakfast was great. Holiday Inn Express is doing everything right for a comfortable stay."
United States
Denise
The price is NT$2,737
NT$3,052 total
includes taxes & fees
Dec 7 - Dec 8
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
View from room
Matlacha on Shoreview

Matlacha on Shoreview

2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (207)
"Staff was very helpful throughout our stay, defnitley be back. Beautiful view, awesome area, very clean room."
United States
Randy
The price is NT$2,040
NT$4,375 total
includes taxes & fees
Dec 2 - Dec 3
Matlacha on Shoreview
Exterior
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3.0 star property
19.9 km from Sanctuary
8.0 out of 10, Very Good, (1020)
"Room was clean and neat, very friendly staff."
United States
Olha
The price is NT$3,175
NT$3,540 total
includes taxes & fees
Dec 2 - Dec 3
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

3.0 star property
22.9 km from Sanctuary
8.4 out of 10, Very Good, (1010)
"Everything about this stay was wonderful. "
United States
John
The price is NT$3,240
NT$3,612 total
includes taxes & fees
Dec 8 - Dec 9
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Suite with King Bed, Beachfront, Balcony | Terrace/patio
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1048)
" Nice place to stay "
United States
Timothy
The price is NT$5,043
NT$6,323 total
includes taxes & fees
Dec 3 - Dec 4
Lani Kai Beachfront Resort
Exterior
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (1677)
"Very nice and clean resort! "
United States
Stephanie
The price is NT$5,340
NT$7,529 total
includes taxes & fees
Dec 2 - Dec 3
Margaritaville Beach Resort Fort Myers
Lobby
Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa

3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1001)
"Stunning Beach View great Staff "
United States
Robert
The price is NT$10,014
NT$12,264 total
includes taxes & fees
Dec 11 - Dec 12
Tween Waters Island Resort & Spa
Exterior
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

3.0 star property
25.4 km from Sanctuary
7.4 out of 10, Good, (1004)
"Great place to stay."
United States
David
The price is NT$2,737
NT$3,052 total
includes taxes & fees
Dec 4 - Dec 5
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Apartment, Multiple Beds, Partial Ocean View | Beach/ocean view
Edison Beach House

Edison Beach House

3.5 star property
21.2 km from Sanctuary
9.4 out of 10, Exceptional, (1567)
"All around great place to stay"
United States
David
The price is NT$12,968
NT$15,509 total
includes taxes & fees
Jan 1 - 2026/1/2
Edison Beach House
Bar (on property)
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3.0 star property
21.6 km from Sanctuary
9.2 out of 10, Wonderful, (1011)
"Nice place very enjoyable "
United States
James
Matanzas Inn Bayside Resort and Marina
Terrace/patio
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3.0 star property
29.5 km from Sanctuary
8.6 out of 10, Excellent, (1021)
"Enjoyed our stay, would definitely choose the Hilton Garden Inn for future stays"
United States
Barbara
The price is NT$3,508
NT$3,911 total
includes taxes & fees
Dec 12 - Dec 13
Hilton Garden Inn Ft Myers
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1045)
"Comfy bed, clean room, good breakfast "
United States
Darwin
The price is NT$2,505
NT$2,793 total
includes taxes & fees
Dec 16 - Dec 17
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1011)
"Great hotel! Very relaxing! "
United States
Dayneris
The price is NT$4,242
NT$5,923 total
includes taxes & fees
Dec 21 - Dec 22
The Westin Cape Coral Resort At Marina Village
Porch
Angler's Inn

Angler's Inn

2.5 star property
18.8 km from Sanctuary
9.4 out of 10, Exceptional, (322)
"Cute Inn in Matlacha. Clean rooms, comfy beds, and a great screened in porch for each room. Town still recovering from Ian, but still a great time. "
United States
Crystal
The price is NT$5,493
NT$6,125 total
includes taxes & fees
Dec 2 - Dec 3
Angler's Inn
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1443)
"The room was very clean, great updated bathroom comfortable beds. Great restaurant onsite, beautiful beach. "
United States
Glenda
The price is NT$6,561
NT$8,100 total
includes taxes & fees
Dec 2 - Dec 3
Sanibel Island Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
Fort Myers featuring a sandy beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Sanibel Historical Museum and Village showing heritage elements

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

J. N. Ding Darling National Wildlife Refuge which includes marine life and dangerous animals

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Periwinkle Way featuring cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Sea School and Dunes Golf and Tennis Club.

Top Sanctuary Hotel Reviews

DiamondHead Beach Resort

DiamondHead Beach Resort

10/10 Excellent
"Suite was large, well-appointed and spotless with a comfortable bed and beautiful view from the balcony. The kitchenette had refrigerator, dishwasher and microwave as well as dishes and utensils. Coste Island Cuisine and Cabanas had good food and live music."
Lyn 2-night trip
Posted 13 hours ago
DiamondHead Beach Resort

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 13 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.