What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

With 11 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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Dates

February 2026

March 2026

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Our top choices for Sanctuary hotels

Matlacha on Shoreview

20.2 km from Sanctuary

Edward

NT$3,684 total

includes taxes & fees

Feb 1 - Feb 2

Suite, 2 Bedrooms, Marina View | Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

The Westin Cape Coral Resort At Marina Village

18.1 km from Sanctuary

Frank

NT$9,306 total

includes taxes & fees

Feb 8 - Feb 9

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Verona

NT$3,071 total

includes taxes & fees

Jan 29 - Jan 30

In-room safe, desk, laptop workspace, blackout drapes

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Anastassia

NT$5,052 total

includes taxes & fees

Feb 1 - Feb 2

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

22.6 km from Sanctuary

Wayne

NT$5,165 total

includes taxes & fees

Feb 8 - Feb 9

Dolphin Key Resort

23.8 km from Sanctuary

Jason

NT$5,999 total

includes taxes & fees

Jan 29 - Jan 30

Deluxe Suite (Second Floor Only) | Terrace/patio

Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

Ellen

NT$9,957 total

includes taxes & fees

Feb 2 - Feb 3

White Orchid Apartments

20 km from Sanctuary

Brooke

NT$3,929 total

includes taxes & fees

Jan 29 - Jan 30

Summerwind Studios

22.6 km from Sanctuary

Micki

NT$3,824 total

includes taxes & fees

Jan 29 - Jan 30

On the beach, sun loungers, beach towels

Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Freda

NT$10,575 total

includes taxes & fees

Jan 29 - Jan 30

TriLuxe Inn & Studios

22.7 km from Sanctuary

Bobbi

NT$4,000 total

includes taxes & fees

Jan 29 - Jan 30

Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Lance

NT$14,434 total

includes taxes & fees

Jan 29 - Jan 30

Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

David

NT$4,145 total

includes taxes & fees

Jan 29 - Jan 30

Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

Brandon

NT$6,197 total

includes taxes & fees

Feb 1 - Feb 2

Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Erica

NT$6,447 total

includes taxes & fees

Feb 5 - Feb 6

Sanibel Inn

East End, 13.8 km from Sanctuary

Rachelle

NT$14,410 total

includes taxes & fees

Feb 3 - Feb 4

Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Jeff

NT$5,298 total

includes taxes & fees

Jan 29 - Jan 30

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

George

NT$4,526 total

includes taxes & fees

Feb 1 - Feb 2

Island Inn

West End, 9.6 km from Sanctuary

Walter

NT$9,788 total

includes taxes & fees

Jan 29 - Jan 30

Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Adam

NT$6,284 total

includes taxes & fees

Jan 31 - Feb 1

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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Sanibel Historical Museum and Village showing heritage elements

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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J. N. Ding Darling National Wildlife Refuge which includes marine life and dangerous animals

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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Periwinkle Way featuring cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

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Top Sanctuary Hotel Reviews

Lani Kai Beachfront Resort

10/10 Excellent

"Beautiful hotel, rooms are fresh and clean, location to die for!!! Restaurants are great, food is delicious, excellent service, highly recommended to stay in this wonderful place."