What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

A resort with a central pool, multiple lounge areas, and a beach view.

1. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Michael

NT$12,817 total

includes taxes & fees

Nov 20 - Nov 21

A spacious kitchen with a large island, white cabinetry, and a view through the windows.

2. South Seas

5.5 km from Sanctuary

Jeremy

NT$11,056 total

includes taxes & fees

Nov 11 - Nov 12

A beach with a variety of seashells and pebbles.

3. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Eldad

NT$7,376 total

includes taxes & fees

Oct 25 - Oct 26

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

4. Casa Ybel Resort

Ybel, 11.6 km from Sanctuary

Yesenia

NT$8,384 total

includes taxes & fees

Oct 25 - Oct 26

A beach with a view of the ocean and a sunset.

5. Island Inn

West End, 9.6 km from Sanctuary

Nicole

NT$10,114 total

includes taxes & fees

Oct 31 - Nov 1

A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

6. Sanibel Inn

East End, 13.8 km from Sanctuary

Tamara

NT$13,024 total

includes taxes & fees

Oct 26 - Oct 27

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

7. Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

Lisa

NT$7,574 total

includes taxes & fees

Oct 26 - Oct 27

A large, clear swimming pool with multiple lounge areas and palm trees.

8. Margaritaville Beach Resort Fort Myers

21.6 km from Sanctuary

Jose

NT$8,103 total

includes taxes & fees

Oct 24 - Oct 25

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

9. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Yunior

NT$8,626 total

includes taxes & fees

Nov 9 - Nov 10

A wooden boardwalk leading to a beach with clear skies and calm waters.

10. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Mauricio

NT$11,357 total

includes taxes & fees

Oct 25 - Oct 26

A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

11. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

Lisa Renee

NT$15,051 total

includes taxes & fees

Oct 25 - Oct 26

A balcony with a table and chairs, large windows, and a view of the sea.

12. The Westin Cape Coral Resort At Marina Village

18.1 km from Sanctuary

Charles

NT$6,403 total

includes taxes & fees

Nov 22 - Nov 23

A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

13. Pink Shell Beach Resort and Marina

20.4 km from Sanctuary

Mario

NT$9,948 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

14. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

MARYTE

NT$3,652 total

includes taxes & fees

Oct 28 - Oct 29

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

15. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

jennifer

NT$3,399 total

includes taxes & fees

Oct 25 - Oct 26

A pathway flanked by palm trees and wooden buildings with thatched roofs.

16. Kona Kai Motel

Mid Island, 12.2 km from Sanctuary

Aurelia

NT$6,000 total

includes taxes & fees

Oct 26 - Oct 27

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

17. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Samantha

NT$2,603 total

includes taxes & fees

Oct 29 - Oct 30

A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

18. Best Western Plus Beach Resort

20.9 km from Sanctuary

Stacy

NT$7,833 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor seating area with wicker chairs and a central table, surrounded by lush greenery and palm trees.

19. THE Palmview AND Sandpiper Inns

Mid Island, 13.1 km from Sanctuary

Callie

NT$11,896 total

includes taxes & fees

Oct 23 - Oct 24

20. The Anchor Inn

Mid Island, 12.8 km from Sanctuary

Ashton

NT$5,632 total

includes taxes & fees

Oct 27 - Oct 28

View all properties

Compare popular hotels in Sanctuary

Property	Property class	Guest rating
Sanibel Island Beach Resort	3.0 star property	9.2 Wonderful 2,377 reviews	View
Island Inn	3.5 star property	9.4 Exceptional 1,164 reviews	View
Off the Charts Inn & Out Island Resort	2.5 star property	9.6 Exceptional 164 reviews	View
South Seas	3.5 star property	8.4 Very good 1,000 reviews	View
Tween Waters Island Resort & Spa	3.0 star property	8.6 Excellent 1,000 reviews	View

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

Margaritaville Beach Resort Fort Myers

10/10 Excellent

"Very good"

Hilton Garden Inn Ft Myers

10/10 Excellent

"I stay often in Fort Myers (family), this is 1st at Garden Inn, I will definitely stay here in the future. Everything was immaculate, staff is friendly and ever so helpful. The rates were less than what I had been paying for someplace a few mins closer to the family. Discovered Garden Inn was <5 mins further, worth the extra few mins at less the cost. We ordered a breakfast to take to our room, cooked to order and plentiful."

Find hotels in Sanctuary, Sanibel

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Star rating

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

2. South Seas

3. Sanibel Island Beach Resort

4. Casa Ybel Resort

5. Island Inn

6. Sanibel Inn

7. Off the Charts Inn & Out Island Resort

8. Margaritaville Beach Resort Fort Myers

9. Marriott Sanibel Harbour Resort & Spa

10. Shalimar Beach Resort

11. Sundial Beach Resort & Spa

12. The Westin Cape Coral Resort At Marina Village

13. Pink Shell Beach Resort and Marina

14. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

15. Residence Inn by Marriott Fort Myers Sanibel

16. Kona Kai Motel

17. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

18. Best Western Plus Beach Resort

19. THE Palmview AND Sandpiper Inns

20. The Anchor Inn

Compare popular hotels in Sanctuary

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Margaritaville Beach Resort Fort Myers

Frequently asked questions

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