What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

A resort with a central pool, multiple lounge areas, and a beach view.

1. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Carol

NT$9,027 total

includes taxes & fees

Nov 8 - Nov 9

A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

2. South Seas

5.5 km from Sanctuary

Jeremy

NT$11,185 total

includes taxes & fees

Nov 11 - Nov 12

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

3. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Elina

NT$8,193 total

includes taxes & fees

Nov 8 - Nov 9

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

4. Casa Ybel Resort

Ybel, 11.6 km from Sanctuary

Sydney

NT$9,486 total

includes taxes & fees

Nov 12 - Nov 13

A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

5. Island Inn

West End, 9.6 km from Sanctuary

Nicole

NT$9,836 total

includes taxes & fees

Dec 1 - Dec 2

A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

6. Sanibel Inn

East End, 13.8 km from Sanctuary

Tamara

NT$13,175 total

includes taxes & fees

Nov 9 - Nov 10

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

7. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Yunior

NT$9,312 total

includes taxes & fees

Dec 3 - Dec 4

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

8. Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

George

NT$6,885 total

includes taxes & fees

Dec 5 - Dec 6

A large, clear swimming pool with multiple lounge areas and palm trees.

9. Margaritaville Beach Resort Fort Myers

21.6 km from Sanctuary

Lance

NT$8,197 total

includes taxes & fees

Dec 6 - Dec 7

A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

10. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

Lisa Renee

NT$14,923 total

includes taxes & fees

Nov 29 - Nov 30

A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

11. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Mauricio

NT$11,489 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

12. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Sherri

NT$3,658 total

includes taxes & fees

Nov 10 - Nov 11

A balcony with a table and chairs, large windows, and a view of the sea.

13. The Westin Cape Coral Resort At Marina Village

18.1 km from Sanctuary

Charles

NT$6,813 total

includes taxes & fees

Nov 15 - Nov 16

A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

14. Best Western Plus Beach Resort

20.9 km from Sanctuary

Stacy

NT$7,924 total

includes taxes & fees

Nov 18 - Nov 19

A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

15. Pink Shell Beach Resort and Marina

20.4 km from Sanctuary

Mario

NT$10,026 total

includes taxes & fees

Nov 15 - Nov 16

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

16. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Samantha

NT$2,926 total

includes taxes & fees

Nov 23 - Nov 24

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

17. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Lora

NT$3,292 total

includes taxes & fees

Nov 22 - Nov 23

18. The Anchor Inn

Mid Island, 12.8 km from Sanctuary

April

NT$6,601 total

includes taxes & fees

Nov 10 - Nov 11

A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

19. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Chris

NT$2,969 total

includes taxes & fees

Nov 11 - Nov 12

A swimming pool with a stone wall and palm trees, surrounded by a building with large windows and outdoor seating.

20. Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

James

NT$4,010 total

includes taxes & fees

Nov 22 - Nov 23

View all properties

Compare popular hotels in Sanctuary

Property	Property class	Guest rating
Off the Charts Inn & Out Island Resort	2.5 star property	9.6 Exceptional 165 reviews	View
The Anchor Inn	2.0 star property	10.0 Exceptional 85 reviews	View
Tween Waters Island Resort & Spa	3.0 star property	8.6 Excellent 1,000 reviews	View
Sanibel Island Beach Resort	3.0 star property	9.2 Wonderful 2,410 reviews	View
South Seas	3.5 star property	8.4 Very good 1,000 reviews	View

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

Sanibel Island Beach Resort

10/10 Excellent

"Amazing experience all around! Super clean, friendly staff and excellent amenities! We’ll definitely be back!"

Margaritaville Beach Resort Fort Myers

10/10 Excellent

"The property was in excellent shape and exceptionally clean. Check-in and check-out were quick and efficient (enjoyed the complimentary margaritas upon check-in!), and the valet was quick to produce our car. The waitstaff at the pool were friendly and informative. There was one overcharging error, but they rectified it quickly when we brought it to their attention. We had a wonderful stay and would definitely come back again!"

Find hotels in Sanctuary, Sanibel

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

2. South Seas

3. Sanibel Island Beach Resort

4. Casa Ybel Resort

5. Island Inn

6. Sanibel Inn

7. Marriott Sanibel Harbour Resort & Spa

8. Off the Charts Inn & Out Island Resort

9. Margaritaville Beach Resort Fort Myers

10. Sundial Beach Resort & Spa

11. Shalimar Beach Resort

12. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

13. The Westin Cape Coral Resort At Marina Village

14. Best Western Plus Beach Resort

15. Pink Shell Beach Resort and Marina

16. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

17. Residence Inn by Marriott Fort Myers Sanibel

18. The Anchor Inn

19. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

20. Doubletree by Hilton Fort Myers at Bell Tower Shops

Compare popular hotels in Sanctuary

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Sanibel Island Beach Resort

Frequently asked questions

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