Find Boutique Hotels in Mission District, CA

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Our top choices for Mission District boutique hotels

Berkeley City Club

Berkeley City Club
2.5 star property
Telegraph District
8.8 out of 10, Excellent, (697)
"Wonderful, beautiful, old world hotel, right in the heart of bustling Berkeley. "
United States
Peter
Berkeley City Club

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
Fisherman's Wharf
8.6 out of 10, Excellent, (2334)
"This place is wonderful. Would definitely stay again!!"
United States
Jenna
The price is NT$3,934
NT$5,740 total
includes taxes & fees
Jan 8 - 2026/1/9
Hotel Zephyr San Francisco

Palihotel San Francisco

Palihotel San Francisco
3.5 star property
Union Square
8.4 out of 10, Very Good, (630)
"Great vibe here and the rooms and so cute . Excellent bar and bar staff . "
United States
Lana
The price is NT$3,143
NT$4,485 total
includes taxes & fees
Dec 28 - Dec 29
Palihotel San Francisco

Hotel Triton

Hotel Triton
4.0 star property
Union Square
8.8 out of 10, Excellent, (1001)
"We had a great stay!"
United States
Jeremy
The price is NT$2,862
NT$4,737 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Triton

Hotel Emblem San Francisco

Hotel Emblem San Francisco
4.0 star property
Union Square
9.4 out of 10, Exceptional, (1001)
"Great place to stay when visiting the City - will return again!"
United States
Chris
The price is NT$3,527
NT$5,409 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Emblem San Francisco

The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton
4.0 star property
Union Square
8.2 out of 10, Very Good, (774)
"Wonderful Stay, Room was Clean. Close to Union Square. Would Stay Here again. "
United States
Raquel
The price is NT$4,122
NT$4,851 total
includes taxes & fees
Dec 28 - Dec 29
The Barnes San Francisco, Tapestry Collection by Hilton

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1000)
"Very professional staff! Central located walking distance to everything!"
United States
Edmundo
The price is NT$5,177
NT$7,395 total
includes taxes & fees
Jan 3 - 2026/1/4
The Clancy, Autograph Collection by Marriott

Harbor Court Hotel

Harbor Court Hotel
4.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1003)
"Room was perfect and customer service amazing!"
United States
Bilal
The price is NT$4,370
NT$6,586 total
includes taxes & fees
Dec 28 - Dec 29
Harbor Court Hotel

The Marker Union Square San Francisco

The Marker Union Square San Francisco
4.0 star property
Union Square
9.0 out of 10, Wonderful, (1126)
"The staff was so fabulous, the hotel is gorgeous, and we are already having the best time!"
United States
Faith
The price is NT$4,389
NT$5,165 total
includes taxes & fees
Jan 3 - 2026/1/4
The Marker Union Square San Francisco

Taj Campton Place

Taj Campton Place
5.0 star property
Union Square
9.2 out of 10, Wonderful, (1000)
"Wonderful Staff and hospitality."
United States
Rachel
The price is NT$5,595
NT$7,671 total
includes taxes & fees
Jan 4 - 2026/1/5
Taj Campton Place
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Mission District Hotel Reviews

Frequently asked questions

What's there to see and do in Mission District?
The bars is one thing to enjoy while you're in the area. Favorite activities and sights around Mission District include Oracle Park, Pier 39, and San Francisco Bay. Some other things you might want to enjoy include SOMA Pilipinas, Victoria Theatre, and SF Armory.
What's the best way to get to my boutique hotel in Mission District?
You have a few options for getting to Mission District. The closest major airport is San Francisco Intl. Airport (SFO), which is located 10 mi (16.1 km) away. You can take advantage of metro transit at 16th Street Mission Station, 24th Street Mission Station, and Right Of Way/20th St Stop.

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