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Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

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Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

1. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,002 reviews)
"Plenty of parking and cozy room."
United States
Katherine
The price is NT$2,980
NT$3,338 total
includes taxes & fees
Oct 22 - Oct 23
Fairfield Inn & Suites by Marriott Fort Pierce
Exterior

2. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"My weekend stay was a 10/10.I will definitely book my next stay here"
United States
Angela
The price is NT$3,140
NT$3,517 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn & Suites Ft. Pierce
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (901 reviews)
"I would definitely stay at this hotel again"
United States
Rodney
The price is NT$3,176
NT$3,557 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (275 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is NT$3,829
NT$4,288 total
includes taxes & fees
Oct 30 - Oct 31
Home2 Suites by Hilton Ft. Pierce I-95
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

5. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,371 reviews)
"Clean room nice staff and awesome view!! Will be staying there again soon!"
United States
Lana
The price is NT$3,553
NT$4,605 total
includes taxes & fees
Oct 18 - Oct 19
Hutchinson Island Hotel
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,001 reviews)
"Very clean friendly staff good breakfast"
United States
riad
The price is NT$2,831
NT$3,171 total
includes taxes & fees
Oct 18 - Oct 19
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

7. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,000 reviews)
"The staff was excellent"
United States
Carlton
The price is NT$1,915
NT$2,145 total
includes taxes & fees
Nov 1 - Nov 2
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1,335 reviews)
"Room was clean. Staff was very helpful respectful and breakfast was sufficient"
United States
Ronald
The price is NT$1,859
NT$2,082 total
includes taxes & fees
Nov 15 - Nov 16
At Home Inn
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

9. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (971 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is NT$2,732
NT$3,060 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Suites Fort Pierce I-95
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

10. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,001 reviews)
"Loved our stay, great staff."
United States
Amy
The price is NT$3,301
NT$3,697 total
includes taxes & fees
Oct 23 - Oct 24
SpringHill Suites Port St. Lucie
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

11. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Easy access and secure parking"
United States
Cameron
The price is NT$4,225
NT$4,732 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn & Suites Vero Beach Downtown
A gym with treadmills, elliptical machines, and a red exercise ball.

12. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,005 reviews)
"Very Helpful and Friendly staff, our room was super clean, and breakfast was great!"
United States
Ahim
The price is NT$3,117
NT$3,491 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites Port St. Lucie, West
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

13. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (918 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is NT$2,463
NT$2,758 total
includes taxes & fees
Nov 1 - Nov 2
Sleep Inn Fort Pierce I-95
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

14. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,003 reviews)
"Great stay"
United States
AEON
The price is NT$3,539
NT$3,963 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Port St. Lucie West by IHG
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

15. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,004 reviews)
"Good place for a short stay"
United States
BRIAN
The price is NT$2,895
NT$3,242 total
includes taxes & fees
Nov 15 - Nov 16
Best Western Port St. Lucie
A spacious lobby with a stone fireplace, comfortable seating, and a bar area.

16. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (722 reviews)
"Perfect stay"
United States
Michelle
The price is NT$3,989
NT$4,468 total
includes taxes & fees
Nov 12 - Nov 13
Staybridge Suites Vero Beach by IHG
A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

17. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
7.0 out of 10, Good, (1,000 reviews)
"Good value"
United States
Cynthia
The price is NT$2,105
NT$2,358 total
includes taxes & fees
Oct 19 - Oct 20
Days Inn & Suites by Wyndham Fort Pierce Midtown
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

18. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,002 reviews)
"My go-to hotel when I need a place to get away!"
United States
Taylor
The price is NT$3,040
NT$3,921 total
includes taxes & fees
Oct 22 - Oct 23
The Royal Inn Beach Hotel Hutchinson Island
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

19. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Eduardo
The price is NT$3,539
NT$3,963 total
includes taxes & fees
Oct 25 - Oct 26
Residence Inn by Marriott Port St. Lucie
A modern bar area with wooden tables and blue chairs, featuring black pendant lights and a large abstract mural on the wall.

20. TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95
3.0 star property
21.9 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,001 reviews)
"Location was convenient , staff was nice , hotel was clean"
United States
Demonica
The price is NT$3,735
NT$4,183 total
includes taxes & fees
Oct 25 - Oct 26
TownePlace Suites by Marriott Port St. Lucie I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa

10/10 Excellent
"The grounds were beautiful and well maintained. Staff was super friendly."
Meghan 1-night trip
Posted 19 hours ago
Hutchinson Shores Resort & Spa

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels can I expect to find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.
Where can I learn more about changing or cancelling my trip to Main Street Fort Pierce?
For additional details about changing or cancelling your trip to Main Street Fort Pierce, head over to our customer service page.
What is there to do in this Fort Pierce neighborhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.

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