A marina with boats, a bridge, and buildings along a waterfront.

Find Resorts & Hotels with Spas in Main Street Fort Pierce, FL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Main Street Fort Pierce Resorts & Hotels with Spas

Next weekend
Nov 6 - Nov 8
In two weeks
Nov 13 - Nov 15

Our top choices for Main Street Fort Pierce hotels with a spa

A spacious lobby with a high ceiling, a large chandelier, and a central seating area.

1. Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa
4.5 star property
25.2 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,005 reviews)
"The hotel was very quiet and relaxing."
United States
Ronald
The price is NT$6,487
NT$8,687 total
includes taxes & fees
Nov 16 - Nov 17
Hutchinson Shores Resort & Spa
A spacious lobby with a modern design, featuring a seating area with a round table and chairs, a decorative wall with vertical elements, and a series of arched windows along the corridor.

2. Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa
4.0 star property
23 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,001 reviews)
"Good hotel ,"
United States
Michael
The price is NT$6,234
NT$8,698 total
includes taxes & fees
Nov 16 - Nov 17
Costa d'Este Beach Resort and Spa
A reception area with wooden reception desks, a sofa, and a wall with a leaf pattern.

3. Kimpton Vero Beach Hotel & Spa by IHG

Kimpton Vero Beach Hotel & Spa by IHG
4.0 star property
23.4 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,003 reviews)
"Everything from the room to the staff was wonderful. Very relaxing stay."
United States
Thomas
The price is NT$7,693
NT$10,325 total
includes taxes & fees
Nov 18 - Nov 19
Kimpton Vero Beach Hotel & Spa by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Main Street Fort Pierce

Pool
Breakfast included

Top Main Street Fort Pierce Hotel Reviews

Hutchinson Island Hotel

Hutchinson Island Hotel

10/10 Excellent
"Hot tub not working. Fishing/sunset pier was fun."
Anthony 2-night trip
Posted 2 days ago
Hutchinson Island Hotel

Frequently asked questions

Looking to vacation at a spa hotel in Main Street Fort Pierce?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the art galleries and shopping in Main Street Fort Pierce—your day trip starts here. Enjoy the riverfront during your vacation. Spa hotels are the perfect way to take a break from your routine and add a layer of luxury to your vacation.
What's there to see and do in Main Street Fort Pierce?
Experience Main Street Fort Pierce and visit Sunrise Theater, Fort Pierce Farmer's Market, and Fort Pierce City Marina. If you have extra time while you're in the area, you might want to stop by Jetty Park Beach and Fort Pierce Inlet State Park.
What is a Main Street Fort Pierce spa hotel?
Spa hotels in Main Street Fort Pierce have on-site spas offering services like facials and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.

Explore a world of travel with Expedia