Find Resorts & Hotels with Spas in Grand Isle, FL

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Check availability on Grand Isle Resorts & Hotels with Spas

No exact matches found, but these alternatives could be just right

Recommended hotels in Grand Isle

Exterior
The Port Inn and Cottages, an Ascend Collection Hotel

The Port Inn and Cottages, an Ascend Collection Hotel

The Port Inn and Cottages, an Ascend Collection Hotel
3.5 star property
Downtown Port St. Joe
9.0 out of 10, Wonderful, (404)
"Great staff, clean and comfortable room "
United States
Karen
The price is NT$4,066
NT$4,554 total
includes taxes & fees
Jan 15 - 2026/1/16
The Port Inn and Cottages, an Ascend Collection Hotel
Free daily continental breakfast
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South
2.5 star property
Port St. Joe
8.6 out of 10, Excellent, (694)
"Room was clean, kitchen very clean, hotel staff was very friendly "
United States
Donna
The price is NT$3,420
NT$3,831 total
includes taxes & fees
Dec 28 - Dec 29
MainStay Suites Port Saint Joe South
Aerial view
Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways
3.5 star property
Port St. Joe
10.0 out of 10, Exceptional, (4)
"Brand new, quaint spot with really comfortable beds. "
United States
Anonymous traveler
The price is NT$4,534
NT$16,957 total
includes taxes & fees
Dec 16 - Dec 17
Cape Cottages by Panhandle Getaways
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Comfort Suites

Comfort Suites

Comfort Suites
2.5 star property
Panama City
8.6 out of 10, Excellent, (715)
"The staff I encountered were polite and very helpful."
United States
Gerard
The price is NT$2,625
NT$2,837 total
includes taxes & fees
Jan 1 - 2026/1/2
Comfort Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Grand Isle Hotel Reviews

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

10/10 Excellent
"Last minute booking, and they had my information and the check in was very easy. The hotel had lost their internet connection, but it was late and had very little impact on my stay. The hotel was clean, the room well equipped, and the free breakfast was very filling."
Bettye 1-night trip
Posted 1 month ago
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
Comfort Suites

Comfort Suites

10/10 Excellent
"Customer service was not helpful with applying for the rewards, but I stay at this exact comfort suites regularly at least once a month. I asked for help with signing up and the front desk, lady was very rude and didn’t even try to help when I asked for help. Other than that I always enjoy my stay here. "
Monica 2-night trip
Posted 2 months ago
Comfort Suites

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Frequently asked questions

Looking to vacation at a spa hotel in Grand Isle?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Spa hotels are the perfect way to take a break from your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Grand Isle?
Enjoy all that Grand Isle has to offer and visit Mexico Beach, Saint Joe Beach, and Windmark Beach. If you have extra time while you're in the area, you might want to see Forgotten Coast Sea Turtle Center and St. Joseph Peninsula State Park.
What is a Grand Isle spa hotel?
Spa hotels in Grand Isle provide lodging and have an on-site spa offering services such as therapies as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.