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Discover 1,331 Downtown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (645)
"Staff was friendly very clean "
The price is NT$2,299
NT$2,826 total
includes taxes & fees
Oct 12 - Oct 13
Quality Inn Seneca Clemson Area US-123
Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Very beautiful place to stay"
The price is NT$3,315
NT$4,115 total
includes taxes & fees
Oct 5 - Oct 6
Lakeside Lodge Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
Balcony

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (194)
"Nice hotel by the lake"
The price is NT$3,923
NT$4,315 total
includes taxes & fees
Oct 8 - Oct 9
Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area
Room, 1 King Bed, Non Smoking | Desk, free cribs/infant beds, rollaway beds, free WiFi

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (701)
"Friendly staff easy check-in. "
The price is NT$2,197
NT$2,417 total
includes taxes & fees
Oct 5 - Oct 6
Days Inn by Wyndham Seneca / Clemson Area
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (772)
"Very friendly and clean "
The price is NT$3,334
NT$3,668 total
includes taxes & fees
Oct 12 - Oct 13
Tru by Hilton Seneca Clemson
Best Western Plus Clemson Hotel & Conference Center
Property amenity

Best Western Plus Clemson Hotel & Conference Center

2.5 star property
8.2 out of 10, Very Good, (1001)
"Excellent stay & so helpful!"
The price is NT$2,559
NT$2,840 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Plus Clemson Hotel & Conference Center
Inn @ Clemson
Lobby lounge

Inn @ Clemson

2.5 star property
8.0 out of 10, Very Good, (1024)
"Very nice staff and great place to stay"
Inn @ Clemson
Woodspring Suites Anderson North I-85
Exterior

Woodspring Suites Anderson North I-85

2.5 star property
7.2 out of 10, Good, (32)
"This was a new clean facility with nice staff. "
The price is NT$2,281
NT$2,532 total
includes taxes & fees
Oct 5 - Oct 6
Woodspring Suites Anderson North I-85
Comfort Inn & Suites Clemson - University Area
Lobby

Comfort Inn & Suites Clemson - University Area

2.5 star property
8.2 out of 10, Very Good, (1000)
"Very good value for this hotel considering its location near Clemson's downtown. Comfortable beds."
The price is NT$2,951
NT$3,275 total
includes taxes & fees
Oct 19 - Oct 20
Comfort Inn & Suites Clemson - University Area
Hampton Inn & Suites Seneca-Clemson Area
Exterior

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
9.4 out of 10, Exceptional, (637)
"The staff were very friendly and helpful. The room was clean and the breakfast was great!"
The price is NT$3,688
NT$4,056 total
includes taxes & fees
Oct 5 - Oct 6
Hampton Inn & Suites Seneca-Clemson Area
The Shepherd Hotel Downtown Clemson
Superior Room, 2 Queen Beds | In-room safe, blackout drapes, soundproofing, iron/ironing board

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (690)
"Great staff, location, comfortable and well maintained property."
The price is NT$5,747
NT$6,380 total
includes taxes & fees
Oct 19 - Oct 20
The Shepherd Hotel Downtown Clemson
Days Inn by Wyndham Clemson
Gazebo

Days Inn by Wyndham Clemson

3.5 star property
7.0 out of 10, Good, (188)
"Great place "
The price is NT$2,571
NT$2,854 total
includes taxes & fees
Oct 12 - Oct 13
Days Inn by Wyndham Clemson
Clemson University's James F. Martin Inn
View from property

Clemson University's James F. Martin Inn

3.0 star property
9.6 out of 10, Exceptional, (937)
"Amazing place to stay. "
The price is NT$4,531
NT$5,030 total
includes taxes & fees
Oct 19 - Oct 20
Clemson University's James F. Martin Inn
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (620)
"Convenient for Clemson visits."
The price is NT$2,714
NT$2,986 total
includes taxes & fees
Oct 10 - Oct 11
Best Western Seneca-Clemson
Courtyard Marriott Clemson
Fireplace

Courtyard Marriott Clemson

3.0 star property
9.2 out of 10, Wonderful, (515)
"Excellent!!! We loved everything about it!!! "
The price is NT$3,809
NT$4,228 total
includes taxes & fees
Oct 9 - Oct 10
Courtyard Marriott Clemson
Holiday Inn Express & Suites Clemson by IHG
Exterior

Holiday Inn Express & Suites Clemson by IHG

2.5 star property
8.8 out of 10, Excellent, (942)
"Had a great stay at this hotel. Conveniently located near restaurants. "
The price is NT$3,442
NT$3,821 total
includes taxes & fees
Oct 19 - Oct 20
Holiday Inn Express & Suites Clemson by IHG
Baymont by Wyndham Anderson Clemson
Outdoor pool

Baymont by Wyndham Anderson Clemson

2.5 star property
7.0 out of 10, Good, (818)
"Clean room | Staff | Parking | Family-friendly"
The price is NT$2,068
NT$2,295 total
includes taxes & fees
Oct 13 - Oct 14
Baymont by Wyndham Anderson Clemson
Quality Inn Clemson near University
Reception

Quality Inn Clemson near University

2.5 star property
7.0 out of 10, Good, (880)
"Shopping is good nears around "
The price is NT$1,980
NT$2,198 total
includes taxes & fees
Oct 12 - Oct 13
Quality Inn Clemson near University
Microtel Inn & Suites by Wyndham Anderson/Clemson
Lobby

Microtel Inn & Suites by Wyndham Anderson/Clemson

2.0 star property
8.2 out of 10, Very Good, (1001)
"Great stay"
The price is NT$2,250
NT$2,498 total
includes taxes & fees
Oct 24 - Oct 25
Microtel Inn & Suites by Wyndham Anderson/Clemson
The Inn at Patrick Square
Reception hall

The Inn at Patrick Square

3.5 star property
9.8 out of 10, Exceptional, (761)
"Beautiful hotel and close to restaurants and bars. "
The price is NT$4,531
NT$5,030 total
includes taxes & fees
Nov 2 - Nov 3
The Inn at Patrick Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown

Find the best Downtown areas and neighborhoods for the activities you enjoy most.

Pine Ridge Point

While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby.

Indian Oaks

While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like Keowee Reservoir and Oconee County Library Seneca Branch.

Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

Keowee Plantation

When in Keowee Plantation, you can plan a visit to Keowee Reservoir and Oconee County Library Seneca Branch, some noteworthy sights in the nearby area.

Top Downtown Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent
"Good breakfast. Friendly staff. Great location. "
David 3-night trip
Posted 2 days ago
Best Western Plus Clemson Hotel & Conference Center

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is Downtown like?

Travelers to the Downtown neighborhood in Seneca will be sure to enjoy their stay. Be sure to check out Seneca Historic District and Oconee County Library Seneca Branch as part of your Downtown travel plans.

Where is the best place to stay in Downtown?

Based on Expedia customer reviews, Quality Inn Seneca Clemson Area US-123 is the highest ranked property in Downtown. This hotel offers free breakfast and free parking.

How many hotels can I expect to find in Downtown?

Expedia has 9 Downtown hotels and other accommodations, and one might make a good home base for venturing out into the greater Seneca area.

If I need to cancel my hotel reservation in Downtown, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to view the best deals in Downtown.

Where can I learn more about changing or cancelling my trip to Downtown?

To find more details about rescheduling or cancelling your trip to Downtown, head over to our customer service page.

What can I see and do in this Seneca neighborhood?

Seneca Historic District, Oconee County Library Seneca Branch, and Bertha Lee Strickland Cultural Museum are just a few attractions to check out in Downtown. As you're discovering the neighborhood, The Gauntlet and Seneca City Hall are some other places worth a visit. Golden Corner Plaza, Oconee Community Theatre, and Applewood Shopping Center are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, be sure to visit other sights like Wyndham Plaza or Cross Creek Plantation Golf.