The Best Hotels Closest to Buffalo Museum of Science in Buffalo for 2026

A large mammoth skeleton in a museum with classical architecture.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Buffalo Museum of Science hotels

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A historic building with a prominent tower and a large entrance.

A grand hallway with a wooden staircase, a chandelier, and a patterned floor.

A traditional living room with a green sofa, a wooden coffee table with books, a blue armchair, and various potted plants.

1. Buffalo Harmony House

Allentown, 3.2 km from Buffalo Museum of Science

Dustin

NT$9,083

NT$10,582 total

includes taxes & fees

Aug 25 - Aug 26

A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

A living room with a fireplace, two leather armchairs, a coffee table, and a chandelier.

A grand staircase with a wooden handrail and a leopard print carpet, leading to a room with a large window and a door with frosted glass panels.

2. The Edward Hotel

Elmwood Village, 2.4 km from Buffalo Museum of Science

Lynne

NT$4,428

NT$6,098 total

includes taxes & fees

Aug 25 - Aug 26

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

A bar area with wooden furniture, a large wooden cabinet, and a clock on the wall.

A pool table in a room with dark walls, large windows, and green upholstered chairs.

A living room with a red wall, white furniture, a fireplace, and a large abstract painting.

3. The Mansion On Delaware Ave

Allentown, 3 km from Buffalo Museum of Science

Jennifer Penfield

NT$6,566

NT$7,535 total

includes taxes & fees

Sep 1 - Sep 2

A two-story building with a white exterior, a red door, and large windows.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

A living room with a fireplace, a chandelier, leather sofas, and a glass coffee table.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

4. Buffalo Guesthouse

Allentown, 2.4 km from Buffalo Museum of Science

ROY

NT$5,543

NT$6,361 total

includes taxes & fees

Aug 26 - Aug 27

A modern hotel lobby with a bar area, seating, and a large TV screen.

A modern indoor swimming pool with clear blue water, surrounded by lounge chairs and a glass-enclosed area.

A modern restaurant with a long counter, bar stools, and a refrigerated display.

A modern hotel lobby with seating areas, a flat-screen TV, and a bookshelf.

5. Residence Inn by Marriott Buffalo Downtown

Allentown, 2.6 km from Buffalo Museum of Science

Christopher

NT$5,389

NT$6,292 total

includes taxes & fees

Aug 30 - Aug 31

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

A modern lobby with a sofa set, coffee table, potted plants, and a large window providing natural light.

6. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 1.9 km from Buffalo Museum of Science

Craig

NT$4,469

NT$5,217 total

includes taxes & fees

Aug 31 - Sep 1

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A hotel lobby with a curved reception desk, a chandelier, a seating area with leather chairs, and a tiled floor.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

A modern gym with cardio machines, a mirrored wall, and a blue accent wall.

7. Best Western on the Avenue

Allentown, 2.8 km from Buffalo Museum of Science

Daisy

NT$4,846

NT$5,658 total

includes taxes & fees

Sep 9 - Sep 10

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A reception desk with a computer, printer, and a vase of flowers.

A modern hotel lobby with seating areas, large windows, and a view of the outdoors.

A modern hotel lobby with green sofas, grey armchairs, and a central table with a vase.

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 3.1 km from Buffalo Museum of Science

NT$4,269

NT$4,984 total

includes taxes & fees

Sep 21 - Sep 22

A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

A casino interior with slot machines, a large illuminated pillar, and comfortable seating areas.

A grand staircase with a decorative railing and a Christmas tree adorned with ornaments and ribbons.

A modern kitchen with a large window, stainless steel appliances, and wooden cabinetry.

9. Summer Street Guest House

Bryant, 3 km from Buffalo Museum of Science

Anthony

NT$11,075

NT$16,364 total

includes taxes & fees

Sep 14 - Sep 15

A lobby with a staircase, seating area, and a view of the outdoors.

A bathroom with a toilet, sink, and shower curtain.

A hotel with a classic brick facade, a glass entrance, and flags.

A hotel room with two beds, a desk, a television, and a window.

10. Lenox Hotel and Suites

Allentown, 2.6 km from Buffalo Museum of Science

Carra

NT$3,398

NT$3,899 total

includes taxes & fees

Aug 30 - Aug 31

A rooftop terrace with wicker furniture, a bar area, and a view of the cityscape.

A bar area with a circular bar counter, multiple hanging light fixtures, and bar stools.

A modern cafe with round tables and chairs, a bar area, and a neon sign.

A modern hotel with a glass facade, multiple floors, and a prominent 'Aloft' sign.

11. Aloft by Marriott Buffalo Downtown

Buffalo Theater District, 3 km from Buffalo Museum of Science

Holly

NT$5,958

NT$6,956 total

includes taxes & fees

Sep 6 - Sep 7

A dining area with a wooden table set for four, surrounded by chairs. There is a kitchen area with cabinets and appliances in the background.

A kitchen with wooden cabinets, a dishwasher, and a dining area with a table and chairs.

A modern living room with a sectional sofa, a dining area, and a kitchen in the background.

A kitchen with wooden cabinets, stainless steel appliances, and a red toaster.

12. 4 Mi to Dtwn: Family Home in Buffalo

Masten Park, 1.4 km from Buffalo Museum of Science

NT$9,462

NT$16,761 total

includes taxes & fees

Aug 25 - Aug 26

A buffet setup with various food items and utensils.

A building with a large illuminated sign reading "Russells STEAKS - CHOPS - AND MORE".

A hotel room with a large bed, a desk with a chair, a bathroom with a bathtub, and a mirror.

A hotel reception desk with a large mirror, a chandelier, and a 'HOTEL' sign.

13. Salvatores Grand Hotel

13.1 km from Buffalo Museum of Science

Carol

NT$5,384

NT$6,125 total

includes taxes & fees

Aug 25 - Aug 26

A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

An outdoor patio area with tables and chairs, string lights, and greenery.

14. Reikart House, Buffalo, a Tribute Portfolio Hotel

8.3 km from Buffalo Museum of Science

Michelle

NT$7,136

NT$8,118 total

includes taxes & fees

Sep 6 - Sep 7

15. Hampton Inn Buffalo - Amherst, NY

10.6 km from Buffalo Museum of Science

Ken

NT$3,710

NT$4,220 total

includes taxes & fees

Sep 7 - Sep 8

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

A hotel with a brick facade, multiple balconies, and a sign for 'The Mosey Hotel & Residences'.

16. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

9 km from Buffalo Museum of Science

Jon

NT$4,820

NT$5,483 total

includes taxes & fees

Aug 30 - Aug 31

A large indoor swimming pool with clear blue water, surrounded by lounge chairs and a sauna area.

A hotel lobby with a seating area featuring sofas, ottomans, and tables. A reception desk and a bar are visible in the background.

A modern hotel room with a large bed, a desk, a TV, and a view of the outdoors.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

17. Hampton Inn Buffalo-Williamsville

9.6 km from Buffalo Museum of Science

Douglas

NT$4,631

NT$5,267 total

includes taxes & fees

Sep 3 - Sep 4

A modern hotel room with a large window, a sofa, a coffee table, and a TV.

A hotel lobby with a seating area, dining tables, and large windows offering views of the cityscape.

A modern kitchen with a central island, bar stools, and built-in appliances.

A spacious bedroom with a large bed, a comfortable armchair, and a view of a body of water through floor-to-ceiling windows.

18. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 4.4 km from Buffalo Museum of Science

Vincent

NT$7,713

NT$9,005 total

includes taxes & fees

Aug 30 - Aug 31

A patio area with outdoor seating, a barbecue grill, and a stone wall.

A modern lounge area with seating, tables, and hanging chairs.

A modern indoor space with a foosball table, seating areas, a mural, and a television screen.

19. Tru by Hilton Williamsville Buffalo Airport

13 km from Buffalo Museum of Science

Michael

NT$4,035

NT$4,590 total

includes taxes & fees

Aug 31 - Sep 1

A spacious lobby with high ceilings, a grand staircase, and a gift shop.

A bar area with red upholstered bar stools, a bar counter, and a chandelier.

A bar area with leather barstools, a bar counter, and a television screen.

A hotel room with two beds, a desk, a chair, a coffee machine, and a large window with curtains.

20. The Delavan Hotel & Spa

12.4 km from Buffalo Museum of Science

JACK

NT$4,005

NT$4,555 total

includes taxes & fees

Aug 31 - Sep 1

View all properties

Compare popular hotels close to Buffalo Museum of Science

Property	Property class	Guest rating
Buffalo Harmony House	10.0 Exceptional 53 reviews	View
The Edward Hotel	9.6 Exceptional 257 reviews	View
The Mansion On Delaware Ave	9.4 Exceptional 1,006 reviews	View
Buffalo Guesthouse	9.4 Exceptional 193 reviews	View
Residence Inn by Marriott Buffalo Downtown	9.2 Wonderful 380 reviews	View

Top Buffalo Museum of Science Hotel Reviews

Wyndham Garden Buffalo Downtown

10/10 Excellent

"Great staff"

Best Western on the Avenue

10/10 Excellent

"We had a very pleasant stay at Best Western on the Avenue. The continental breakfast was very good, with a nice variety of options, and everything was clean and well organized. Our room was a comfortable size — just right for our needs. There was a fridge, although it did not have a mini freezer, and there was no microwave in the room. The staff were polite, welcoming, and very helpful. One thing that really impressed us was the cleanliness of the hotel. For a pet-friendly hotel, you would never know it when entering the room — it smelled fresh and clean and was clearly very well maintained. Overall, a comfortable, clean, and welcoming place to stay. We had a very good experience and would happily stay here again."

Buffalo Guesthouse

10/10 Excellent

"The staff was super helpful when I showed up early and we're able to work with me to get a room quickly. The rooms are homey and comfortable. I have stayed a couple times and highly recommend the experience!"

The Mansion On Delaware Ave

8/10 Good

"We like the vibe of the property. Something different from the standard marriot or holiday inn. Lots of charm and character. Nice neighborhood. Mostly clean, but. the bathtub could use new grout or a thorough cleaning around the tub. Bed was very comfortable. I would go back."

Hampton Inn & Suites Buffalo Downtown

10/10 Excellent

"The great location, very clean room and bathroom, good breakfast and friendly staff! Thanks for the hospitality!"

InnBuffalo off Elmwood

10/10 Excellent

"This property surpassed our expectations. Very comfortable and clean. Everything we needed was available. The available snacks and drinks were a fantastic touch. The house has been preserved beautifully. The outside yard/patio space and front porch were covered and perfect for relaxing. By far one of my favorite stays amongst my travels. Highly recommend."

Summer Street Guest House

10/10 Excellent

"Loved the house, the owner, and his dog!"

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

You can find out about the history of Buffalo when you stop by Buffalo Central Terminal. Experience the entertainment choices and great live music in this vibrant area.

See properties

War Memorial Stadium

Explore the great outdoors at War Memorial Stadium, a lovely green space in Buffalo. Experience the area's acclaimed theater scene and great live music.

See properties

Paul Robeson Theater

Enjoy a show at Paul Robeson Theater, a theater with a story to tell in Buffalo. Experience the area's great live music and acclaimed theater scene.

See properties

African American Cultural Center

Enjoy a stop at African American Cultural Center, an entertaining place to visit in Buffalo. Experience the area's acclaimed theater scene and great live music.

See properties

Broadway Market

You can enjoy retail therapy at Broadway Market during your stay in Buffalo. Experience the area's acclaimed theater scene and entertainment choices.

See properties

Koessler Athletic Center

Catch an event at Koessler Athletic Center during your trip to Buffalo.

See properties

Montante Cultural Center

Enjoy an outing to Montante Cultural Center during your stay in Buffalo.

See properties

Hellenic Orthodox Church of the Annunciation

After visiting Hellenic Orthodox Church of the Annunciation, make a plan to see the other sights and activities in Buffalo.

See properties

Frequently asked questions

What's the area like around Buffalo Museum of Science?

Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Buffalo Museum of Science?

Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. It's located 1.2 mi (1.9 km) from Buffalo Museum of Science. Other good choices within 5 miles include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I be able to find close to Buffalo Museum of Science?

Expedia has 14 hotels and other accommodations within a mile from Buffalo Museum of Science.

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the top deals on offer near Buffalo Museum of Science.

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

For more information about picking new dates or cancelling your stay near Buffalo Museum of Science, go to https://www.expedia.com/service/.

What can I see and do near Buffalo Museum of Science?

Study the collections at Buffalo AKG Art Museum, Buffalo History Museum, or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower, and Peace Bridge. You can watch performances at Kleinhans Music Hall, Town Ballroom, and Helium Comedy Club - Buffalo if you're interested in local theater.

Find hotels near Buffalo Museum of Science, Buffalo from NT$3,899

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Buffalo Museum of Science hotels

1. Buffalo Harmony House

2. The Edward Hotel

3. The Mansion On Delaware Ave

4. Buffalo Guesthouse

5. Residence Inn by Marriott Buffalo Downtown

6. Wyndham Garden Buffalo Downtown

7. Best Western on the Avenue

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

9. Summer Street Guest House

10. Lenox Hotel and Suites

11. Aloft by Marriott Buffalo Downtown

12. 4 Mi to Dtwn: Family Home in Buffalo

13. Salvatores Grand Hotel

14. Reikart House, Buffalo, a Tribute Portfolio Hotel

15. Hampton Inn Buffalo - Amherst, NY

16. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

17. Hampton Inn Buffalo-Williamsville

18. Buffalo Marriott at LECOM HARBORCENTER

19. Tru by Hilton Williamsville Buffalo Airport

20. The Delavan Hotel & Spa

Compare popular hotels close to Buffalo Museum of Science

Top Buffalo Museum of Science Hotel Reviews

Wyndham Garden Buffalo Downtown

Best Western on the Avenue

Buffalo Guesthouse

The Mansion On Delaware Ave

Hampton Inn & Suites Buffalo Downtown

InnBuffalo off Elmwood

Summer Street Guest House

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

War Memorial Stadium

Paul Robeson Theater

African American Cultural Center

Broadway Market

Koessler Athletic Center

Montante Cultural Center

Hellenic Orthodox Church of the Annunciation

Frequently asked questions

Explore a world of travel with Expedia