A coastal landscape with clear turquoise waters, rocky hills, and a distant mountain range.

Samos Prefecture 5 Stars Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Samos Prefecture 5 Star Hotels

Next weekend
In two weeks

Our top choices for Samos Prefecture 5-star hotels

1. Casa Cook Samos

Casa Cook Samos
5.0 star property
Samos
9.4 out of 10, Exceptional, (152 reviews)
"Peaceful hotel with helpful staff"
United Kingdom
Margaret Anne
Casa Cook Samos

2. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
5.0 star property
Samos
9.6 out of 10, Exceptional, (122 reviews)
"Amazing place: clean, plenty of sunbeds on perfect private beach, lots of breakfast options"
Germany
Artsem
Proteas Blu Resort - Adults Only

3. Doryssa Seaside Resort

Doryssa Seaside Resort
5.0 star property
Samos
8.8 out of 10, Excellent, (186 reviews)
"A gorgeous property, great location, courteous staff… would def stay there again!! Perfect room!!😊"
United States
Athanasios
Doryssa Seaside Resort

4. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
5.0 star property
Samos
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Samos Prefecture.
Still don't see what you're looking for?
See all properties in Samos Prefecture.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Samos Prefecture

Check out the local area in Samos Prefecture—home to attractions like Balos Beach and Lemonakia Beach.

A beach with blue chairs and a hammock overlooking the sea.
Photo by Erdem Yücel
Open Photo by Erdem Yücel

Top Samos Prefecture Hotel Reviews