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Find Business Hotels in Upstate South Carolina, SC

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Check availability on Upstate South Carolina Business Hotels

Tonight
Dec 21 - Dec 22
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Dec 22 - Dec 23
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Dec 26 - Dec 28
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Jan 2 - Jan 4

Our top choices for Upstate South Carolina business-friendly hotels

Free daily full breakfast
Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.6 out of 10, Excellent, (420)
"Great place to stay"
United States
Timothy
The price is NT$2,462
NT$2,683 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express Gaffney by IHG
Reception
Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85
2.5 star property
Spartanburg
8.6 out of 10, Excellent, (1000)
"Everything was great "
United States
Annie M
The price is NT$2,459
NT$2,729 total
includes taxes & fees
Jan 9 - 2026/1/10
Hampton Inn Spartanburg-North I-85
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham Greer/Spartanburg Area

Super 8 by Wyndham Greer/Spartanburg Area

Super 8 by Wyndham Greer/Spartanburg Area
2.0 star property
Greer
7.2 out of 10, Good, (525)
"My stay at Super 8 was quite remarkable . I really enjoyed the place."
United States
Rick
The price is NT$2,119
NT$2,395 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Greer/Spartanburg Area
Lobby lounge
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Terrace/patio
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (795)
"Clean rooms, friendly staff, great game room/hang out space. "
United States
karen
The price is NT$3,080
NT$3,388 total
includes taxes & fees
Dec 28 - Dec 29
Tru by Hilton Seneca Clemson
Lobby
Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville
2.5 star property
Greer
8.6 out of 10, Excellent, (728)
"Staff very friendly, clean spacious room"
United States
Arthur
The price is NT$2,954
NT$3,220 total
includes taxes & fees
Dec 31 - 2026/1/1
Comfort Inn & Suites Greer - Greenville
Property amenity
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (204)
"Nice hotel by the lake"
United States
Mike
The price is NT$3,630
NT$3,993 total
includes taxes & fees
Dec 28 - Dec 29
Fairfield Inn & Suites Seneca Clemson Univ Area
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (665)
"Friendly check in, clean room."
United States
connie
The price is NT$2,320
NT$2,740 total
includes taxes & fees
Dec 28 - Dec 29
Quality Inn Seneca Clemson Area US-123
Interior
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1019)
"Great room, staff and location. "
United States
Neil
The price is NT$2,990
NT$3,289 total
includes taxes & fees
Dec 28 - Dec 29
Embassy Suites Greenville Golf Resort & Conference Center
Free daily continental breakfast
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.0 out of 10, Wonderful, (1417)
"Clean room, great selection for breakfast, easy check in and check out"
United States
Angelica
The price is NT$2,415
NT$2,656 total
includes taxes & fees
Dec 28 - Dec 29
Best Western Plus Greenville I-385 Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Upstate South Carolina Hotel Reviews

Hyatt Regency Greenville

Hyatt Regency Greenville

10/10 Excellent
"Great staff and the valet is awesome. Very courteous and accommodating "
Corrie 1-night trip
Posted 23 hours ago
Hyatt Regency Greenville

Frequently asked questions

How much do business-friendly hotels in Upstate South Carolina cost?
You can expect to pay between NT$2,395 and NT$3,993 per night for business-friendly hotels in Upstate South Carolina. Terrific deals on stays that are suitable for work-related travelers are a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Upstate South Carolina?
That depends on your destination in Upstate South Carolina. Lots of business travelers to Greenville choose Homewood Suites by Hilton Greenville Downtown. This 3-stars property has a barbecue grill and a swimming pool. SpringHill Suites by Marriott Greenville Downtown is another excellent option if you're arranging a meeting or working remotely in Greenville. A swimming pool and a barbecue grill are some of the useful amenities at this 2.5-stars retreat. You can choose from multiple business-friendly hotels in Upstate South Carolina that have a total average guest review rating of 8.6.
How many business-friendly hotels are there in Upstate South Carolina?
When your next meeting or conference takes you someplace in Upstate South Carolina, you'll have 144 business-friendly hotels to choose from.
What are the best cheap business-friendly hotels in Upstate South Carolina?
That depends on which corner of Upstate South Carolina work is taking you. If you're headed to Greenville, SpringHill Suites by Marriott Greenville Downtown combines affordability with business-friendly amenities. A terrace and a barbecue grill are a couple of its many conveniences. On your way to Spartanburg? Look up Tru by Hilton Spartanburg. WiFi and a playground help make this cheaper property a favorite with corporate visitors. Business-friendly hotels start at just NT$2,395 per night, so your next work trip doesn't have to stretch your finances. There are loads of fun and free things to do wherever you're headed in Upstate South Carolina. If business is taking you to Greenville, try to find time to swing by Greenville County Museum of Art. You can also go sightseeing without spending a dime in Spartanburg. Spartanburg Regional Hospital is one of the most popular free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in Upstate South Carolina?
Expedia's business-friendly motels in Upstate South Carolina come with amenities that are the ideal mix of work and play. One of our best options is Urban Boutique Hotel, BW Signature Collection in Greenville. Located around 3 kilometers northeast of the downtown area, WiFi and front desk services are the start of its many conveniences. Another stay that appeals to corporate travelers is Days Inn by Wyndham Greenville. It's approximately 8 kilometers east of the center of Greenville and features a swimming pool, front desk services and more.There are a ton of things to keep you entertained when you're not hard at work in Greenville. The Peace Center and Frankie's Fun Park should be on your sightseeing checklist.
Are there any family-friendly hotels in Upstate South Carolina that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Upstate South Carolina. If you're on your way to Greenville, take a look at SpringHill Suites by Marriott Greenville Downtown. It comes with useful amenities like complimentary breakfast and WiFi and has a 2.5-stars rating. Another option to consider is Hampton Inn & Suites Greenville-Downtown-RiverPlace. This 2.5-stars stay in Greenville is perfect for both leisure and business travelers and offers complimentary breakfast, room service and more. Greenville offers loads of family-friendly attractions when you're ready to discover the sights. Frankie's Fun Park and Greenville Zoo will keep your crew entertained.
Are there any 5-star business-friendly hotels in Upstate South Carolina?
In Upstate South Carolina, 5-star business-friendly hotels are difficult to come by. However, there are some 4-star properties that cater to corporate travelers. If you're making tracks to Greenville for work, base yourself at The Westin Poinsett Greenville. It comes with handy amenities including pillow top mattresses and room service. Or, put your laptop down and feet up at Greenville Marriott, also in Greenville. Take advantage of its conveniences including a swimming pool and pillow top mattresses.
Why book your business-friendly hotel in Upstate South Carolina with Expedia?
We're here to help you find a suitable business-friendly hotel when work takes you on the road. From free parking and WiFi to gyms and on-site restaurants, our properties have the things you'll need to get the job done.
How can I find cheap business-friendly hotels in Upstate South Carolina?
When work takes you to Upstate South Carolina, our "business friendly" filter will help you find the right hotel. From WiFi to workspaces and meeting rooms, they come with the amenities you need for a productive and comfortable stay. You can also narrow your search by your preferred star rating and budget to see the most affordable properties.
What is there to do in Upstate South Carolina near my business-friendly hotel?
The most important travel accessory for your Upstate South Carolina business journey is a good itinerary for your free time! The Peace Center, Greenville Zoo and The Children's Museum of the Upstate are some of the well-known sights if you're staying in Greenville. Spartanburg also has plenty of superb attractions, such as Spartanburg Memorial Auditorium, Spartanburg Regional History Museum and Chapman Cultural Center.

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