Find Resorts & Hotels with Spas in St. Charles, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on St. Charles Resorts & Hotels with Spas

Tonight
Dec 7 - Dec 8
Tomorrow
Dec 8 - Dec 9
Next weekend
Dec 12 - Dec 14
In two weeks
Dec 19 - Dec 21

Top St. Charles Resorts & Hotels with Spas

Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 star property
St. Charles
8.4 out of 10, Very Good, (1001)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is NT$4,753
NT$6,073 total
includes taxes & fees
Dec 14 - Dec 15
Ameristar Casino Resort and Spa
Couples treatment rooms, hot tub, body treatments, aromatherapy
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is NT$12,964
NT$15,159 total
includes taxes & fees
Jan 1 - 2026/1/2
Four Seasons Hotel St Louis
Massages
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1483)
"Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area. "
United States
Jenifer
The price is NT$3,956
NT$4,782 total
includes taxes & fees
Dec 28 - Dec 29
21C Museum Hotel St Louis
Body treatments, aromatherapy, hot stone massages, deep-tissue massages
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is NT$15,588
NT$18,197 total
includes taxes & fees
Dec 21 - Dec 22
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find out more about St. Charles

Top St. Charles attractions for a relaxing vacation

St. Charles, Missouri offers a delightful blend of relaxation and adventure for travelers seeking hotels with spas. Start your journey with a visit to the historic Main Street, lined with charming boutiques, restaurants, and art galleries, perfect for a leisurely stroll after a rejuvenating spa session. The nearby Frontier Park provides scenic river views and walking trails, ideal for unwinding and connecting with nature. Families can enjoy a day at the St. Charles City Parks, which feature playgrounds and picnic areas, making it a great spot for children to play while parents indulge in some pampering. For a unique experience, consider exploring the local wineries; many offer tastings and tours with tranquil surroundings that enhance your relaxation. After a day of activities, retreat to a spa hotel in the heart of the historic district, where you can enjoy top amenities and attentive service, ensuring you feel pampered throughout your stay.

Find the best hotels & resorts with spas in St. Charles

For those seeking relaxation and rejuvenation in St. Charles, Missouri, these top hotels offer exceptional spa amenities that promise a tranquil escape. Discover the perfect haven to unwind and pamper yourself during your stay.

Ameristar Casino Resort and Spa

  • Why it's great for tailored spa getaway: Ameristar Casino Resort and Spa stands out as a premier destination for travelers seeking a luxurious spa experience, an excellent guest review rating of 8.4. This resort features a full-service spa where guests can indulge in an array of treatments including body treatments, massages, and hydrotherapy sessions, ensuring a rejuvenating retreat right at their fingertips.
  • Other amenities: In addition to its spa offerings, the resort provides a wealth of amenities to enhance every guest's stay. Guests can enjoy the soothing ambiance of the hot tub, relax by the resort pool, or take advantage of fitness facilities open 24 hours. The hotel also features a poolside bar for refreshing drinks, onsite dining options, and concierge services to help plan the perfect getaway. With nearby winery tours and golf opportunities, guests have plenty of options to explore beyond the spa.
  • Nearby attractions: Ameristar Casino St. Charles - 0.01 miles, Historic Main Street - 0.68 miles, Lewis & Clark Boathouse and Nature Center - 0.71 miles

Top St. Charles Hotel Reviews

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent
"Clean Room, the view was amazing, the game room was perfect to help calm my daughter the morning of her procedure at the Children’s Hospital. "
Shane 1-night trip
Posted 1 day ago
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in St. Charles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in St. Charles?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, and a 24-hour fitness center. Treat yourself to a facial, body scrub, or hydrotherapy at Ara.
How many spa hotels will I find in St. Charles?
Among Expedia's 158 accommodation options in St. Charles, there is 1 spa hotel.
What's there to see and do in St. Charles?
Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail, and St Charles Convention Center. If you have some spare time during your trip, you might want to check out Ameristar Casino St. Charles and Fast Lane Classic Cars.
What is a St. Charles spa hotel?
Spa hotels in St. Charles provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.