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Find Business Hotels in Southern Illinois, IL

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Check availability on Southern Illinois Business Hotels

Our top choices for Southern Illinois business-friendly hotels

Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1002)
"Hotel is very clean and staff is also friendly."
United States
Tonya
The price is NT$2,032
NT$2,438 total
includes taxes & fees
Jan 2 - 2026/1/3
Drury Inn & Suites Marion
Exterior
Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1000)
"Clean room, excellent staff."
United States
Nancy
The price is NT$3,251
NT$3,641 total
includes taxes & fees
Jan 10 - 2026/1/11
Holiday Inn Express & Suites Effingham by IHG
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1567)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is NT$2,938
NT$3,324 total
includes taxes & fees
Dec 25 - Dec 26
Drury Plaza Hotel Mt. Vernon
Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1005)
"reception was great, room clean, and the price was right."
United States
tom
The price is NT$2,082
NT$2,373 total
includes taxes & fees
Jan 4 - 2026/1/5
Super 8 by Wyndham Mt. Vernon IL
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (903)
"Great place to stay."
United States
Stephen
The price is NT$2,258
NT$2,506 total
includes taxes & fees
Dec 31 - 2026/1/1
SureStay Hotel by Best Western Whittington Rend Lake
Lobby sitting area
Baymont by Wyndham Marion

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1065)
"This place was nice for the money and our 1 night stay. "
United States
Charles
The price is NT$2,287
NT$2,744 total
includes taxes & fees
Jan 2 - 2026/1/3
Baymont by Wyndham Marion
Room, 2 Queen Beds, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1001)
"Clean rooms and kind staff"
United States
Linda
The price is NT$2,917
NT$3,237 total
includes taxes & fees
Jan 11 - 2026/1/12
Country Inn & Suites by Radisson, Effingham, IL
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (600)
"Very beautiful place to stay "
United States
Valerie
The price is NT$3,770
NT$4,222 total
includes taxes & fees
Jan 1 - 2026/1/2
Best Western Plus Centralia Hotel & Suites
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1002)
"Clean room, excellent location, pet friendly. Would definitely book again. "
United States
Misty
The price is NT$2,890
NT$3,237 total
includes taxes & fees
Jan 11 - 2026/1/12
La Quinta Inn & Suites by Wyndham Effingham
Desk, blackout drapes, iron/ironing board, free WiFi
Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70
2.5 star property
Greenville
8.4 out of 10, Very Good, (415)
"Room was clean and comfortable."
United States
Michael
The price is NT$2,834
NT$3,145 total
includes taxes & fees
Jan 4 - 2026/1/5
Comfort Inn & Suites Greenville I-70
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Gteat facility. Wonderful staff, clean facility, great rooms, and an amazing evening 'snack'."
John 1-night trip
Posted 4 days ago
Drury Inn & Suites St. Louis O'Fallon, IL

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Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between NT$2,373 and NT$4,222 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travelers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travelers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 8.9.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at NT$2,373 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travelers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're traveling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travelers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favorite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're traveling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.