A monument with a statue on top, in front of a large building with columns.

Independent South Carolina Midlands hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 24 - Sep 25
Tomorrow
Sep 25 - Sep 26
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4
Save an average of 15% on thousands of hotels when you're signed in

Top South Carolina Midlands Hotel Reviews

Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

10/10 Excellent
"Just overall excellent! Thank you!"
Carol 1-night trip
Posted 1 hour ago
Tru By Hilton Columbia Downtown
Sleep Inn Columbia

Sleep Inn Columbia

8/10 Good
"Nice, clean, safe and as described. Good stay"
crystal 2-night trip
Posted 4 hours ago
Sleep Inn Columbia
Country Inn & Suites by Radisson, Columbia, SC

Country Inn & Suites by Radisson, Columbia, SC

8/10 Good
"had a very nice stay , it was quiet the bed was very comfortable, breakfast was tasty. My main concern that the property is very old , needs upgrading , needs a paint job badly outside . Was very disappointed with the heating pool and jacuzzi because the water was cold . Very nice staff."
vanetta 1-night trip
Posted 12 hours ago
Country Inn & Suites by Radisson, Columbia, SC
The Lantern Hotel Columbia

The Lantern Hotel Columbia

10/10 Excellent
"Love this hotel! The staff were incredible; love the mission of the hotel! Great hotel bar with good food options. Great location. Couldn’t have picked a better spot!"
Francis 1-night trip
Posted 15 hours ago
The Lantern Hotel Columbia
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

10/10 Excellent
"Great stay! Would definitely stay again!"
Vincent 1-night trip
Posted 23 hours ago
Quality Inn & Suites Florence Civic Center
Motel 6 Fort Mill, SC - Charlotte

Motel 6 Fort Mill, SC - Charlotte

8/10 Good
"The front desk representative was very professional upon check in. I am not always good with names, but you should know who she is. The original reservation was for a Queen with refrigerator, microwave, ironing board and hair dryer. The Housekeeper didn’t have this room set for reservation. However, The front desk was made an immediate reservation to accommodate me and I got a Double Bed Combination with Refrigerator, Microwave, Iron board, and hair dryer. She was nice enough to go and physically check this room, before giving me my keys. Kudos to your front desk representative!"
Mary Roslyn 1-night trip
Posted 1 day ago
Motel 6 Fort Mill, SC - Charlotte
Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista

10/10 Excellent
"Great location, clean rooms, friendly staff."
Jeanne 1-night trip
Posted 3 days ago
Cambria Hotel Columbia Downtown The Vista

Explore a world of travel with Expedia