The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious lobby with modern seating, large windows, and a city view.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Pauline

NT$4,316

NT$4,798 total

includes taxes & fees

Sep 20 - Sep 21

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Claudine

NT$4,228

NT$5,072 total

includes taxes & fees

Sep 28 - Sep 29

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Jason

NT$4,945

NT$5,488 total

includes taxes & fees

Sep 13 - Sep 14

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

4. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marius

NT$6,442

NT$7,319 total

includes taxes & fees

Sep 27 - Sep 28

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Michelle

NT$4,891

NT$5,428 total

includes taxes & fees

Oct 4 - Oct 5

A covered outdoor area with a wooden railing, chairs, and tables.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A two-story house with a front porch, a central entrance, and a small garden area.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

6. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

"This house is an older and rustic, but the vibe is fantastic! Rooms were well kept and stocked with the necessities. Very quiet and peaceful even though it is a very short walking distance from downtown Sioux Falls (5 to 8 walk depending on what you wanted to do). Shops, Food, Bars, and Entertainment was super convenient to get to. Check in and out was very simple. I would recommend this place to anyone and will definitely stay there again."

Teachey Kent

NT$3,391

NT$4,237 total

includes taxes & fees

Sep 14 - Sep 15

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A modern lobby with seating areas, a large pillar, and a wall mural.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

7. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Christins

NT$4,126

NT$4,779 total

includes taxes & fees

Oct 4 - Oct 5

A buffet with labeled containers of omelets and other dishes.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A reception area with a glass door entrance, a reception desk, and a computer station.

A snack and beverage display with various brands and products.

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

John

NT$3,133

NT$3,500 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

9. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Stacia

NT$3,639

NT$4,530 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk with a computer, a television, and a couch.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

10. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

NT$3,008

NT$3,363 total

includes taxes & fees

Sep 18 - Sep 19

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

11. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Margie

NT$3,004

NT$3,358 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

12. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Darrel

NT$2,579

NT$2,892 total

includes taxes & fees

Sep 13 - Sep 14

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A dining room with a wooden table, six chairs, and a chandelier.

13. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveler

NT$8,018

NT$9,110 total

includes taxes & fees

Sep 20 - Sep 21

A reception area with a counter, a food mart sign, and a security camera.

A hotel room with two beds, a desk, a chair, and a TV.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

14. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Michael

NT$1,850

NT$2,093 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

Two vending machines in a hallway with a sign that reads "VENDORS".

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

15. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

NT$2,492

NT$2,797 total

includes taxes & fees

Sep 13 - Sep 14

16. Sioux Fall Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Randy

NT$2,246

NT$2,527 total

includes taxes & fees

Sep 13 - Sep 14

An indoor swimming pool with clear blue water, surrounded by a tiled deck, and a seating area with chairs and tables.

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a clear view of the building's facade.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

A hotel room with a bed, a sofa, a desk, and a chair.

17. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

Patricia

NT$3,334

NT$3,721 total

includes taxes & fees

Oct 11 - Oct 12

A deck with outdoor furniture, a fire pit, and a view of a body of water.

A modern hotel lobby with a dining area, seating arrangements, and a kitchen in the background.

A reception area with a herringbone-patterned wall, a reception desk, and seating area with chairs and a table.

A modern Hyatt Place hotel with a glass entrance canopy and a brick facade.

18. Hyatt Place Sioux Falls South

Mall District, 3.8 km from Sioux Empire Medical Museum

Ruth

NT$3,702

NT$4,125 total

includes taxes & fees

Sep 20 - Sep 21

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

19. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

matthew

NT$3,786

NT$4,216 total

includes taxes & fees

Sep 20 - Sep 21

A banquet table with a white tablecloth, adorned with greenery and the initials "R&R".

A play area with slides and a climbing structure.

A hotel room with a large bed, a separate bathroom with a bathtub, a desk, and a television.

A reception desk with a wooden finish, a white countertop, and a shelf with various items including a coffee machine.

20. Holiday Inn Express & Suites Brandon by IHG

15.7 km from Sioux Empire Medical Museum

Barbara

NT$3,250

NT$3,767 total

includes taxes & fees

Oct 11 - Oct 12

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 314 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,201 reviews	View
Hotel On Phillips	9.6 Exceptional 1,574 reviews	View
Canopy By Hilton Sioux Falls Downtown	9.6 Exceptional 265 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 671 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Highpoint Hotel

10/10 Excellent

"Room was clean. Staff were friendly."

Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"Nice property was beyond expectations... friendly and helpful staff. Was nice to have a restaurant in Bahr on site and have staff that was attentive. Rooms were clean overall great experience."

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"Nice room"

Hilton Garden Inn Sioux Falls Downtown

10/10 Excellent

"The staff would not provide me with a detailed receipt for my stay."

Valley Inn

8/10 Good

"It was what you would expect for the price. Decent place, room was clean."

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 132 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. Other good choices close by include Home2 Suites By Hilton Sioux Falls/Sanford Medical Center and Valley Inn.

How many hotels will I be able to find close to Sioux Empire Medical Museum?

Expedia has 132 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

Where can I learn more about changing or cancelling my trip in the area near Sioux Empire Medical Museum?

For more details about changing or cancelling your stay near Sioux Empire Medical Museum, go to https://www.expedia.com/service/.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum, and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Find hotels near Sioux Empire Medical Museum, Sioux Falls from NT$2,093

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Treat yourself

Be picky

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Canopy By Hilton Sioux Falls Downtown

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

6. Historic Victorian Inn

7. Hilton Garden Inn Sioux Falls Downtown

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

9. Holiday Inn Sioux Falls-City Centre by IHG

10. The Center Inn

11. Country Inn & Suites by Radisson, Sioux Falls

12. Valley Inn

13. Historic Twin Tudors Inn

14. Ramada by Wyndham Sioux Falls

15. WoodSpring Suites Sioux Falls

16. Sioux Fall Inn

17. Comfort Inn & Suites at Sanford Sports Complex

18. Hyatt Place Sioux Falls South

19. Staybridge Suites Sioux Falls Southwest by IHG

20. Holiday Inn Express & Suites Brandon by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Highpoint Hotel

Holiday Inn Sioux Falls-City Centre by IHG

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Hilton Garden Inn Sioux Falls Downtown

Valley Inn

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions

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