The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious living room with a fireplace, large windows, and modern furniture.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious lobby with modern seating, large windows, and a city view.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

NT$3,890

NT$4,331 total

includes taxes & fees

Oct 18 - Oct 19

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Jordyn

NT$4,256

NT$5,106 total

includes taxes & fees

Oct 15 - Oct 16

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Frank

NT$4,778

NT$5,305 total

includes taxes & fees

Oct 4 - Oct 5

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A snack and beverage display area with various snacks and drinks.

4. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Tami

NT$3,440

NT$3,838 total

includes taxes & fees

Oct 18 - Oct 19

A patio with wicker chairs and a round table with a fire pit.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

NT$3,902

NT$4,344 total

includes taxes & fees

Oct 18 - Oct 19

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

NT$4,871

NT$5,599 total

includes taxes & fees

Nov 1 - Nov 2

A covered outdoor area with a wooden railing, chairs, and tables.

A two-story house with a front porch, a central entrance, and a small garden area.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

7. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

Jackie

NT$3,385

NT$4,236 total

includes taxes & fees

Oct 13 - Oct 14

A buffet with labeled containers of omelets and other dishes.

A snack and beverage display with various brands and products.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

NT$3,345

NT$3,733 total

includes taxes & fees

Oct 18 - Oct 19

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A modern lobby with seating areas, a large pillar, and a wall mural.

9. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Todd

NT$3,944

NT$4,583 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Stacey

NT$3,521

NT$4,407 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk with a computer, a television, and a couch.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A sign for Center Inn with a parking lot and buildings in the background.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

11. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

NT$3,037

NT$3,395 total

includes taxes & fees

Oct 3 - Oct 4

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

12. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

NT$3,358

NT$3,747 total

includes taxes & fees

Oct 18 - Oct 19

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

13. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

NT$2,920

NT$3,267 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

14. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Darrel

NT$2,604

NT$2,921 total

includes taxes & fees

Oct 8 - Oct 9

An indoor pool area with a slide, seating, and tropical decor.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

A lobby with a stone fire feature, seating area, and a reception desk.

15. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

NT$1,977

NT$2,232 total

includes taxes & fees

Oct 25 - Oct 26

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A dining room with a wooden table, six chairs, and a chandelier.

16. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveler

NT$8,096

NT$9,199 total

includes taxes & fees

Oct 8 - Oct 9

17. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Stephanie

NT$1,745

NT$1,978 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

Two vending machines in a hallway with a sign that reads "VENDORS".

18. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

NT$2,517

NT$2,824 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a counter, a food mart sign, and a security camera.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A hotel room with two beds, a desk, a chair, and a TV.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

19. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

NT$1,823

NT$2,064 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A modern kitchen with wooden cabinets, a marble countertop, and various appliances.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

NT$3,874

NT$4,313 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 348 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,227 reviews	View
Hotel On Phillips	9.6 Exceptional 1,603 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,001 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 676 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Great stay. Quiet room! Nice breakfast!"

Baymont by Wyndham Sioux Falls

8/10 Good

"Great room at an even better price."

Valley Inn

10/10 Excellent

"Everything was great"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

See properties

Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 136 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels will I be able to find close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

Where can I learn more about changing or cancelling my trip in the area near Sioux Empire Medical Museum?

For more details about changing or cancelling your stay near Sioux Empire Medical Museum, go to https://www.expedia.com/service/.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum, and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Find hotels near Sioux Empire Medical Museum, Sioux Falls from NT$1,978

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Hampton Inn Sioux Falls

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

6. Canopy By Hilton Sioux Falls Downtown

7. Historic Victorian Inn

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

9. Hilton Garden Inn Sioux Falls Downtown

10. Holiday Inn Sioux Falls-City Centre by IHG

11. The Center Inn

12. Sheraton Sioux Falls Hotel & Convention Center

13. Country Inn & Suites by Radisson, Sioux Falls

14. Valley Inn

15. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

16. Historic Twin Tudors Inn

17. Sioux Falls Inn

18. WoodSpring Suites Sioux Falls

19. Ramada by Wyndham Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

Baymont by Wyndham Sioux Falls

Valley Inn

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions

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