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Discover Cherokee Seneca hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Cherokee Seneca hotels

Derby City Gaming & Hotel - A Churchill Downs Property
1 bedroom, premium bedding, in-room safe, desk

Derby City Gaming & Hotel - A Churchill Downs Property

4.0 star property
9.4 out of 10, Exceptional, (1404)
"Great staff and clean hotel"
Derby City Gaming & Hotel - A Churchill Downs Property
Hampton Inn & Suites By Hilton Louisville East Oxmoor
Indoor pool

Hampton Inn & Suites By Hilton Louisville East Oxmoor

2.5 star property
9.6 out of 10, Exceptional, (100)
"Great stay "
The price is NT$3,435
NT$4,042 total
includes taxes & fees
Sep 30 - Oct 1
Hampton Inn & Suites By Hilton Louisville East Oxmoor
Wyndham Garden Louisville KY
Desk, laptop workspace, blackout drapes, iron/ironing board

Wyndham Garden Louisville KY

2.5 star property
8.0 out of 10, Very Good, (130)
"The staff was very friendly, and the breakfast options were great. We loved the four nights we stayed there, and we will be back and will be recommending the hotel to our friends and family. "
The price is NT$2,579
NT$3,035 total
includes taxes & fees
Sep 5 - Sep 6
Wyndham Garden Louisville KY
Courtyard by Marriott Louisville Northeast
Terrace/patio

Courtyard by Marriott Louisville Northeast

3.0 star property
8.8 out of 10, Excellent, (1000)
"Great stay!"
The price is NT$2,579
NT$3,035 total
includes taxes & fees
Sep 5 - Sep 6
Courtyard by Marriott Louisville Northeast
Hotel Genevieve part of JdV by Hyatt
Hypo-allergenic bedding, in-room safe, desk, laptop workspace

Hotel Genevieve part of JdV by Hyatt

4.0 star property
9.2 out of 10, Wonderful, (943)
"Hotel is clean, staff was friendly and helpful. The entire hotel has a unique vibe that is just so cool. The food at the restaurant/roof top bar was amazing. Within walking distance to many restaurants and bars as well. "
The price is NT$4,150
NT$4,883 total
includes taxes & fees
Sep 7 - Sep 8
Hotel Genevieve part of JdV by Hyatt
Hilton Garden Inn Jeffersonville Louisville North
Exterior

Hilton Garden Inn Jeffersonville Louisville North

3.0 star property
9.6 out of 10, Exceptional, (332)
"Everything was very clean and a beautiful hotel"
The price is NT$3,225
NT$3,644 total
includes taxes & fees
Sep 27 - Sep 28
Hilton Garden Inn Jeffersonville Louisville North
Comfort Inn & Suites Clarksville - Louisville North
Exterior

Comfort Inn & Suites Clarksville - Louisville North

2.5 star property
9.0 out of 10, Wonderful, (977)
"The presidential suite was huge! Definitely will stay again. "
The price is NT$3,163
NT$3,574 total
includes taxes & fees
Sep 7 - Sep 8
Comfort Inn & Suites Clarksville - Louisville North
Holiday Inn Express & Suites Louisville Downtown by IHG
Exterior

Holiday Inn Express & Suites Louisville Downtown by IHG

2.5 star property
8.8 out of 10, Excellent, (1533)
"We liked that the property was located conveniently in walking distance of several dining and attractions. "
The price is NT$3,071
NT$3,614 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express & Suites Louisville Downtown by IHG
Home2 Suites By Hilton Shepherdsville Louisville South
Terrace/patio

Home2 Suites By Hilton Shepherdsville Louisville South

3.0 star property
9.4 out of 10, Exceptional, (204)
"It was a very quick overnight trip but this place was perfect. "
The price is NT$3,378
NT$3,760 total
includes taxes & fees
Sep 28 - Sep 29
Home2 Suites By Hilton Shepherdsville Louisville South
Galt House Hotel Trademark Collection by Wyndham
4 restaurants, breakfast, lunch, dinner served; American cuisine

Galt House Hotel Trademark Collection by Wyndham

4.0 star property
9.0 out of 10, Wonderful, (3567)
"Great location, easy to walk everywhere "
The price is NT$4,672
NT$5,497 total
includes taxes & fees
Sep 7 - Sep 8
Galt House Hotel Trademark Collection by Wyndham
Best Western Louisville South / Shepherdsville
Exterior

Best Western Louisville South / Shepherdsville

2.5 star property
8.6 out of 10, Excellent, (844)
"Always enjoy my stay at this location!"
The price is NT$2,323
NT$2,586 total
includes taxes & fees
Sep 9 - Sep 10
Best Western Louisville South / Shepherdsville
Red Roof Inn Georgetown, IN - Louisville West
Exterior

Red Roof Inn Georgetown, IN - Louisville West

2.0 star property
8.4 out of 10, Very Good, (982)
"Very comfortable, clean stay"
The price is NT$2,287
NT$2,585 total
includes taxes & fees
Sep 7 - Sep 8
Red Roof Inn Georgetown, IN - Louisville West
The Brown Hotel
Lobby

The Brown Hotel

4.5 star property
9.4 out of 10, Exceptional, (1062)
"Would definitely stay here again"
The price is NT$4,672
NT$5,497 total
includes taxes & fees
Sep 7 - Sep 8
The Brown Hotel
Fairfield Inn & Suites by Marriott Louisville Airport
Lobby

Fairfield Inn & Suites by Marriott Louisville Airport

2.5 star property
8.8 out of 10, Excellent, (623)
"Rooms were very clean and staff were very helpful and polite. "
The price is NT$2,856
NT$3,360 total
includes taxes & fees
Sep 6 - Sep 7
Fairfield Inn & Suites by Marriott Louisville Airport
Tempo By Hilton Louisville Downtown Nulu
2 restaurants, breakfast served

Tempo By Hilton Louisville Downtown Nulu

3.5 star property
9.4 out of 10, Exceptional, (718)
"Wonderful hotel ! "
The price is NT$3,889
NT$4,576 total
includes taxes & fees
Sep 28 - Sep 29
Tempo By Hilton Louisville Downtown Nulu
Ramada by Wyndham Sellersburg/Louisville North
Lobby

Ramada by Wyndham Sellersburg/Louisville North

2.5 star property
8.4 out of 10, Very Good, (1005)
"The breakfast was perfect, the location was convenient, the price was great. "
The price is NT$2,454
NT$2,773 total
includes taxes & fees
Sep 8 - Sep 9
Ramada by Wyndham Sellersburg/Louisville North
Clarion Pointe Louisville East
Standard Room, 2 Queen Beds, Non Smoking | Premium bedding, pillowtop beds, desk, iron/ironing board

Clarion Pointe Louisville East

2.5 star property
8.4 out of 10, Very Good, (1104)
"Everything is fantastic here. I stay every week and I'd hate to stay anywhere else!"
The price is NT$2,159
NT$2,540 total
includes taxes & fees
Sep 7 - Sep 8
Clarion Pointe Louisville East
Best Western Premier Airport/Expo Center Hotel
Standard Room, 2 Queen Beds, Non Smoking, Microwave | Premium bedding, pillowtop beds, desk, laptop workspace

Best Western Premier Airport/Expo Center Hotel

3.5 star property
8.6 out of 10, Excellent, (914)
"Great stay "
The price is NT$2,702
NT$3,180 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Premier Airport/Expo Center Hotel
The Grady
Deluxe Single Room, 1 King Bed, River View | View from room

The Grady

4.0 star property
9.4 out of 10, Exceptional, (1004)
"Wonderful stay- amazing staff!"
The price is NT$6,191
NT$7,284 total
includes taxes & fees
Sep 28 - Sep 29
The Grady
Embassy Suites Louisville Downtown
Dinner served

Embassy Suites Louisville Downtown

4.0 star property
9.0 out of 10, Wonderful, (1019)
"Very nice clean hotel and wonderful breakfast. I would definitely stay there again"
The price is NT$4,591
NT$5,401 total
includes taxes & fees
Sep 7 - Sep 8
Embassy Suites Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most.
Louisville showing signage and street scenes as well as a small group of people

Downtown Louisville

3 out of top 10 points of interest in this area

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

Fairgrounds

1 out of top 10 points of interest in this area

While visiting Fairgrounds, you might make a stop by sights like Freedom Hall and Kentucky Kingdom.

Jeffersontown

Jeffersontown is known for its abundant dining options, and you can plan a trip to Jeffersontown Commons Shopping Center and Bluegrass Indoor Karting while you're in town.

Conrad Caldwell House showing heritage elements and signage

Old Louisville

Boasting Victorian architecture and the highest concentration of stained glass windows in residential homes, Old Louisville offers a walkable neighborhood with pedestrian-only streets, diverse dining options, and attractions like Central Park and the Conrad-Caldwell House.

St. Matthews

Major shopping destination with the fifth-largest mall in Kentucky, Mall St. Matthews, and smaller centers along Shelbyville Road. Don't miss the historic St. Matthew's Episcopal Church and Holy Trinity.

Top Cherokee Seneca Hotel Reviews

Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

10/10 Excellent
"Second time staying here. Staff is helpful, parking is good, room was clean and comfortable. Easy access to get around town. "
Tammy 1-night trip
Posted 3 days ago
Crowne Plaza Louisville Airport Expo Ctr by IHG

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Explore a world of travel with Expedia

Frequently asked questions

What is Cherokee Seneca like?

You'll be sure to have fun visiting Louisville's Cherokee Seneca neighborhood.

If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to review top deals in Cherokee Seneca.

Where can I learn more about changing or cancelling my trip to Cherokee Seneca?

To find more details about changing or cancelling your trip to Cherokee Seneca, head over to our customer service page.

What is there to do around this Louisville neighborhood?

Peterson-Dumesnil House, Historic Frankfort Avenue, and Colonel Sanders' Grave are just a few of the places to visit in and around Cherokee Seneca. Muhammad Ali Gravesite and Mid City Mall Shopping Center are also worth a visit when you're out sightseeing in Louisville.