Find Luxury Hotels in Greenville, MS

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Recommended hotels in Greenville

Cotton House, Cleveland, a Tribute Portfolio Hotel

Cotton House, Cleveland, a Tribute Portfolio Hotel
3.5 star property
Cleveland
9.0 out of 10, Wonderful, (623)
"I enjoyed my stay."
United States
Janeka
The price is NT$4,935
NT$5,379 total
includes taxes & fees
Jan 1 - 2026/1/2
Cotton House, Cleveland, a Tribute Portfolio Hotel

Tru By Hilton Greenville

Tru By Hilton Greenville
2.5 star property
Greenville
8.0 out of 10, Very Good, (534)
"Clean rooms very nice staff"
United States
Dwayne
The price is NT$4,887
NT$5,327 total
includes taxes & fees
Jan 4 - 2026/1/5
Tru By Hilton Greenville

Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa
3.5 star property
Greenville
7.8 out of 10, Good, (1002)
"Yes! The staff were excellent and the food is always delicious. I always stay here when I’m in town 🤗"
United States
Fiyinfolu
The price is NT$3,649
NT$4,014 total
includes taxes & fees
Dec 29 - Dec 30
Harlow's Casino Resort & Spa

Holiday Inn Express and Suites Greenville by IHG

Holiday Inn Express and Suites Greenville by IHG
2.5 star property
Greenville
8.0 out of 10, Very Good, (693)
"Very well kept-up older property in a smaller town. Friendly staff; quiet and comfortable even though it was on a busy four lane road."
United States
Debra
The price is NT$4,998
NT$5,498 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Express and Suites Greenville by IHG

Hotel 27

Hotel 27
2.0 star property
Greenville
9.0 out of 10, Wonderful, (273)
"Very nice stay! "
United States
Ericniesha
The price is NT$4,055
NT$4,460 total
includes taxes & fees
Dec 30 - Dec 31
Hotel 27

Super 8 by Wyndham Indianola

Super 8 by Wyndham Indianola
2.0 star property
Indianola
7.2 out of 10, Good, (377)
"Great value for your money."
United States
Michael
The price is NT$2,829
NT$3,084 total
includes taxes & fees
Jan 11 - 2026/1/12
Super 8 by Wyndham Indianola
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Greenville

Greenvilleand its attractions for luxury travelers

Greenville, Mississippi, offers a unique blend of Southern charm and luxurious experiences for the discerning traveler. Begin your journey at the historic Greenville Symphony Orchestra, where you can enjoy world-class performances in an elegant setting that showcases local talent. For those with a taste for the outdoors, the nearby Lake Ferguson provides opportunities for fishing and boating, with some luxury hotels offering waterfront views that create a serene atmosphere. Food enthusiasts will delight in the vibrant dining scene, including the renowned Doe's Eat Place, famous for its mouthwatering steaks and hospitable service, ensuring a memorable culinary experience. Art lovers can explore the Greenville Arts Council, which often features local exhibits and events, allowing you to immerse yourself in the city’s artistic vibe. Finally, a stroll along the Mississippi River at the scenic Riverwalk is perfect for winding down after a day of exploration, with picturesque views that are best enjoyed from a luxury hotel balcony. The downtown area, with its upscale accommodations, provides easy access to these attractions while ensuring a pampered stay, with attentive service ready to cater to your every need.

Find the best luxury hotels and resorts in Greenville

For travelers seeking a luxurious escape in Greenville, Mississippi, these hotels offer opulent amenities and unparalleled service to elevate your stay. Indulge in the finest accommodations and experiences that embody luxury.

Harlow's Casino Resort & Spa

  • Why it's great for a luxury retreat: Harlow's Casino Resort & Spa is a premier destination for luxury travelers, featuring elegant suites adorned with Egyptian cotton sheets and premium bedding, ensuring a restful stay. With a solid review rating of 7.8, guests can unwind in the opulence of their accommodations while enjoying access to a full-service spa, offering a variety of rejuvenating treatments from massages to body scrubs.
  • Other amenities: Guests can take advantage of the 24-hour fitness facilities to maintain their workout routine, or relax by the pool with sun loungers for ultimate relaxation. The resort also offers traditional hotel design, treatment rooms for manicures and pedicures, and aromatherapy treatments for a soothing experience. Additional features include free self-parking, daily housekeeping, and a convenience store for any essentials during your stay.
  • Nearby attractions: Mississippi River - 3.32 miles, Harlow's Casino Resort & Spa - 0.47 miles, Warfield Point Park - 2.75 miles

Top Greenville Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Greenville?
Use Expedia to arrange your flight to Greenville, MS (GLH-Mid Delta Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Greenville offers. During your visit, you might want to enjoy the restaurants which Greenville is known for.
When can I expect good weather in Greenville?
Planning for the weather is a good way to make your trip to Greenville relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 49°F. Average annual precipitation for Greenville is 56 inches.
What's there to see and do in Greenville?
Experience Greenville with a stop at 1927 Flood Museum, Trop Casino Greenville, and Greenville Country Club. If you have a bit of extra time while you're in the area, you might want to check out Harlow's Casino Resort & Spa and Mississippi River.

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