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Discover 1,744 Grand Center hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

White House at Grand Central
White House at Grand Central

Grand Center Inn
Grand Center Inn

Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch

Pear Tree Inn St. Louis Airport
Pear Tree Inn St. Louis Airport

Drury Inn & Suites St. Louis Union Station
Drury Inn & Suites St. Louis Union Station
Where to stay in Grand Center

Downtown St. Louis
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Creve Coeur
- Hotels in St. Charles Historic District
- Hotels in Downtown West
- Hotels in Soulard
- Hotels in The Hill
- Hotels in University City
- Hotels in Midtown
- Hotels in Ladue
- Hotels in Tower Grove South
- Hotels in The Grove
- Hotels in Dogtown
- Hotels in Lafayette Square
- Hotels in Shaw
- Hotels in The Gate
- Hotels in Southwest Garden
- Hotels in Benton Park
- Hotels in Tower Grove East
Hotels near popular St. Louis Attractions
- Hotels near Fox Theater
- Hotels near Sheldon Concert Hall
- Hotels near Pulitzer Foundation for the Arts
- Hotels near Contemporary Art Museum St. Louis
- Hotels near St. Louis Symphony Orchestra
- Hotels near Grandel Theater
- Hotels near .ZACK Theater
- Hotels near Powell Hall
- Hotels near Powell Symphony Hall
- Hotels near St. Alphonsus Liguori Catholic Church
More Hotel Options in Grand Center
- Adventure Hotels in Grand Center
- Business Hotels in Grand Center
- Hotels with Hot Tubs in Grand Center
- Hotels with WiFi in Grand Center
- Hotels with a Pool in Grand Center
- Pet-friendly Hotels in Grand Center
- Resorts & Hotels with Spas in Grand Center
- Romantic Hotels in Grand Center
- Shopping Hotels in Grand Center
Hotels Close to Nearby Airports
Grand Center Hotels by Star Rating
Explore more hotels
- 21C Museum Hotel St Louis
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Pear Tree Inn St. Louis Airport
- Marriott St. Louis Grand
- River City Casino & Hotel
- Forest Park Hotel by MDR
- AC Hotel St. Louis Clayton
- Moonrise Hotel
- Drury Inn & Suites St. Louis Union Station
- Hilton St. Louis at the Ballpark
- Aloft St. Louis Cortex
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West