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Find Business Hotels in Eastern South Dakota, SD

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Check availability on Eastern South Dakota Business Hotels

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Eastern South Dakota business-friendly hotels

Room, Multiple Beds, Accessible, Non Smoking | Desk, laptop workspace, soundproofing, iron/ironing board
Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex
2.5 star property
Northwest Sioux Falls
9.6 out of 10, Exceptional, (908)
"Perfect stay. This is what clean, quiet and convenient looks like at an affordable price. "
United States
Tiffany
The price is NT$2,844
NT$3,183 total
includes taxes & fees
Jan 4 - 2026/1/5
Comfort Inn & Suites at Sanford Sports Complex
Exterior
AmericInn by Wyndham Hartford SD

AmericInn by Wyndham Hartford SD

AmericInn by Wyndham Hartford SD
2.5 star property
Hartford
9.2 out of 10, Wonderful, (781)
"Great rooms, pool, breakfast."
United States
Kate
The price is NT$2,458
NT$2,672 total
includes taxes & fees
Jan 4 - 2026/1/5
AmericInn by Wyndham Hartford SD
Exterior
Holiday Inn Express & Suites Sioux City North-Event Center by IHG

Holiday Inn Express & Suites Sioux City North-Event Center by IHG

Holiday Inn Express & Suites Sioux City North-Event Center by IHG
2.5 star property
Dakota Dunes
9.4 out of 10, Exceptional, (751)
"Easy check-in, quiet accommodations, good power in the shower."
United States
Rick
The price is NT$2,703
NT$3,059 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express & Suites Sioux City North-Event Center by IHG
Exterior
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls
3.0 star property
Mall District
9.2 out of 10, Wonderful, (1555)
"Great place "
United States
Keegan
The price is NT$2,508
NT$2,815 total
includes taxes & fees
Jan 18 - 2026/1/19
La Quinta Inn & Suites by Wyndham Sioux Falls
Lobby lounge
Clarion Pointe Sioux Falls Airport

Clarion Pointe Sioux Falls Airport

Clarion Pointe Sioux Falls Airport
2.5 star property
Northwest Sioux Falls
8.8 out of 10, Excellent, (1009)
"Very clean and well maintained hotel. The hot tub and pool were nice and the breakfast was great! "
United States
Charles
The price is NT$2,712
NT$3,038 total
includes taxes & fees
Jan 4 - 2026/1/5
Clarion Pointe Sioux Falls Airport
Front of property
AeroStay Hotel

AeroStay Hotel

AeroStay Hotel
2.5 star property
North Sioux Falls
8.8 out of 10, Excellent, (1041)
"VERY CLEAN ROOM, FRIENDLY AND HELPFUL STAFF, ADEQUATE BREAKFAST"
United States
DUANE
The price is NT$4,527
NT$5,464 total
includes taxes & fees
Dec 30 - Dec 31
AeroStay Hotel
Exterior
My Place Hotel - Brookings, SD

My Place Hotel - Brookings, SD

My Place Hotel - Brookings, SD
3.0 star property
Brookings
9.2 out of 10, Wonderful, (731)
"Very awesome room and the price was excellent!!!"
United States
TODD
The price is NT$3,112
NT$3,445 total
includes taxes & fees
Jan 4 - 2026/1/5
My Place Hotel - Brookings, SD
Desk, blackout drapes, soundproofing, iron/ironing board
Days Inn by Wyndham Sioux Falls Airport

Days Inn by Wyndham Sioux Falls Airport

Days Inn by Wyndham Sioux Falls Airport
2.0 star property
North Sioux Falls
7.2 out of 10, Good, (1004)
"Decent place to stay everyone was nice and helpful "
United States
Henrietta
The price is NT$1,576
NT$1,792 total
includes taxes & fees
Jan 19 - 2026/1/20
Days Inn by Wyndham Sioux Falls Airport
3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls
7.8 out of 10, Good, (1466)
"staff was friendly "
United States
Rob
The price is NT$2,019
NT$2,278 total
includes taxes & fees
Jan 4 - 2026/1/5
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Indoor pool
Grandstay Hotel And Suites Luverne

Grandstay Hotel And Suites Luverne

Grandstay Hotel And Suites Luverne
2.5 star property
Luverne
9.2 out of 10, Wonderful, (740)
"Beds were super comfy! "
United States
Kurt
Grandstay Hotel And Suites Luverne
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Eastern South Dakota Hotel Reviews

Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

10/10 Excellent
"Front desk staff made check in/out easy. Staff are friendly and courteous. The room was comfortable and clean."
Marilee 1-night trip
Posted 2 days ago
Days Inn by Wyndham Sioux Falls Empire

Frequently asked questions

How much do business-friendly hotels in Eastern South Dakota cost?
Rates for business hotels in Eastern South Dakota range between NT$1,792 and NT$5,464 per night. No matter your budget, Expedia can help you find the ideal space to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Eastern South Dakota?
There are multiple business-friendly hotels in Eastern South Dakota with a total average guest review rating of 8.7, so you're sure to find a place that suits your needs. Heading to Sioux Falls? Hotel On Phillips is a top choice for corporate travelers. This 2.5-stars option includes amenities such as pillow top mattresses and a Champagne service. Fairfield Inn & Suites Sioux Falls Airport also scores top marks from business guests. Make use of pillow top mattresses and a swimming pool at this 3-stars escape in Sioux Falls.
How many business-friendly hotels are there in Eastern South Dakota?
There are 114 business-friendly hotels in Eastern South Dakota. When work takes you out of town, Expedia makes it easy to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Eastern South Dakota?
That depends on which part of Eastern South Dakota work is taking you. If you're off to Sioux Falls, Hotel On Phillips meets the needs of business travelers at an affordable price. Pillow top mattresses and a cafe are among its many conveniences. On your way to Mitchell? Consider staying at Hampton Inn Mitchell. A swimming pool and designer toiletries help make this cheaper property a top pick for corporate visitors. Business-friendly hotels start at NT$1,792 per night, so that important work trip doesn't have to stretch your finances. Eager to see the sights of Eastern South Dakota without blowing the budget? Take a break from your work events to visit popular free attractions like St. Joseph Cathedral in Sioux Falls. Mitchell also has loads of things to do that don't cost a dime, including Dakota Discovery Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Eastern South Dakota that are also business friendly?
If you're traveling for business in Eastern South Dakota and bringing the family along with you, Expedia will help you locate a cozy and convenient stay. Clubhouse Hotel Suites Sioux Falls in Sioux Falls is an excellent option for those juggling work and leisure. This 3-stars property comes with all the amenities you'll need, like complimentary breakfast and a children's pool. Holiday Inn & Suites Sioux Falls - Airport, an IHG Hotel is another fantastic choice in Sioux Falls. Enjoy the best of both worlds — combine corporate travel and quality time with your family at this 3-stars property. WiFi and laundry facilities are just two of the many conveniences you'll find here. When you've finished work, it's time to explore Sioux Falls with the kids. Popular family-friendly attractions include Great Plains Zoo and Wild Water West.
Why book your business-friendly hotel in Eastern South Dakota with Expedia?
With conveniences like meeting rooms, 24-hour room service and on-site restaurants, our business-friendly properties come with everything you'll need to settle that big contract — and then chill! Enter your preferred dates and travel destination and Expedia will help you with everything else.
How can I find cheap business-friendly hotels in Eastern South Dakota?
When work takes you to Eastern South Dakota, our "business friendly" filter will help you find the perfect hotel. From included breakfast and free WiFi to meeting rooms and workspaces, they come with the amenities you need to get the job done. Another tip? Narrow your search by your budget and preferred star rating to view the most affordable accommodations.
What is there to do in Eastern South Dakota near my business-friendly hotel?
There are so many things to keep you entertained in Eastern South Dakota. If you're off to Sioux Falls, you'll want to check out Great Plains Zoo, Washington Pavilion of Arts and Science and St. Joseph Cathedral. Planning to stay in Mitchell? Dakota Discovery Museum, Corn Palace and Mitchell Aquatic Center are popular attractions here.

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