Find & Book the Best Hotels in Cape Girardeau County for 2026

Top Cities in Cape Girardeau County

A calm body of water, a sandy beach, and a forested area in the distance.

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Cape Girardeau County hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

NT$3,585 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

2. The Riverview

Cape Girardeau

Alyssa

NT$4,098 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

3. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

NT$2,591 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

4. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

NT$3,595 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

5. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

NT$3,262 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

6. Drury Inn & Suites Jackson MO

Jackson

Thomas

NT$2,822 total

includes taxes & fees

Oct 12 - Oct 13

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

NT$2,894 total

includes taxes & fees

Oct 5 - Oct 6

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

8. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

Samuel

NT$3,235 total

includes taxes & fees

Oct 11 - Oct 12

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

9. Quality Inn Cape Girardeau North

Cape Girardeau

Danny

NT$2,156 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

NT$3,626 total

includes taxes & fees

Oct 8 - Oct 9

A modern retail area with a display of local items and snacks.

11. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

NT$3,233 total

includes taxes & fees

Oct 8 - Oct 9

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

12. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

NT$4,505 total

includes taxes & fees

Oct 12 - Oct 13

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

13. Town House Inn Cape Giradreau

Cape Girardeau

Joshua

NT$2,599 total

includes taxes & fees

Oct 1 - Oct 2

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

14. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

NT$3,792 total

includes taxes & fees

Oct 8 - Oct 9

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

15. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

NT$2,650 total

includes taxes & fees

Oct 22 - Oct 23

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

16. Town House Inn

Jackson

Taylor

NT$2,452 total

includes taxes & fees

Oct 5 - Oct 6

A rustic wooden cabin with a porch, outdoor seating, and a view of a lush green landscape.

17. Private Getaway on 270 Acres w/ Lake: Swim & Canoe

Advance

A spacious living area with a sofa, a coffee table, and a TV.

18. Deck & Large Yard! Family Haven in Cape Girardeau

Cape Girardeau

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top Cape Girardeau County Hotel Reviews

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"trodo estubo excelente gracias por sus servicios"

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

10/10 Excellent

"The room was clean. The staff were nice. Breakfast was great. Many choices to choose from. Hot items biscuits and gravy, turkey sausage, small cheese omelette, warm cinnamon rolls. Make your own pancakes. Cereal, pastry, fruit, boiled eggs, yogurt, milk, three juices, coffee maker that grinds the beans and makes an individual cup of coffee."

Drury Inn & Suites Jackson MO

10/10 Excellent

"We had such a wonderful stay at this hotel! The entire property was very clean and well cared for. You could really tell that they take pride in keeping the rooms and common areas in great condition. The staff were incredibly friendly, welcoming, and personable, which made us feel right at home. The breakfast was delicious, with everything kept fresh and clean. My three kids also enjoyed spending time in the pool, and I was impressed by how spotless and well maintained the pool area was as well. Overall, we had a fantastic stay. Everything was comfortable, clean, and welcoming, it truly felt like a home away from home. We would definitely stay here again!"

Search Hotels in Cape Girardeau County

Change your mind

Treat yourself

Be picky

Top Cities in Cape Girardeau County

Cape Girardeau

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Cape Girardeau County hotels

1. Drury Plaza Hotel Cape Girardeau Conference Center

2. The Riverview

3. Pear Tree Inn Cape Girardeau West

4. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

5. Drury Inn & Suites Cape Girardeau

6. Drury Inn & Suites Jackson MO

7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

8. Candlewood Suites Cape Girardeau by IHG

9. Quality Inn Cape Girardeau North

10. Fairfield Inn & Suites by Marriott Cape Girardeau

11. Tru By Hilton Cape Girardeau

12. Courtyard by Marriott Cape Girardeau Downtown

13. Town House Inn Cape Giradreau

14. Hampton Inn Cape Girardeau I 55 East

15. Comfort Suites Jackson-Cape Girardeau

16. Town House Inn

17. Private Getaway on 270 Acres w/ Lake: Swim & Canoe

18. Deck & Large Yard! Family Haven in Cape Girardeau

Top Cape Girardeau County Hotel Reviews

Candlewood Suites Cape Girardeau by IHG

Explore a world of travel with Expedia

Go further with the Expedia app