Photo by Nancy Gates
Find Business Hotels in Central South Dakota, SD
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Central South Dakota Business Hotels
Our top choices for Central South Dakota business-friendly hotels
AmericInn by Wyndham Chamberlain - Conference Center
AmericInn by Wyndham Chamberlain - Conference CenterChamberlain
8.6 out of 10, Excellent, (1000)
"Very clean, staff is great"
Thomas
The price is NT$3,271
NT$3,618 total
includes taxes & fees
Jan 10 - 2026/1/11
8.2 out of 10, Very Good, (1001)
"Clean room and friendly staff."
Deborah
The price is NT$2,498
NT$2,778 total
includes taxes & fees
Jan 10 - 2026/1/11
8.4 out of 10, Very Good, (878)
"Room neat, clean and quiet. Would stay again."
William
The price is NT$2,681
NT$2,914 total
includes taxes & fees
Jan 2 - 2026/1/3
9.4 out of 10, Exceptional, (1000)
"Very nice place to stay, owners were great!
"
jeffrey
9.0 out of 10, Wonderful, (776)
"The hot tub was really nice."
Donald
The price is NT$4,289
NT$4,662 total
includes taxes & fees
Dec 20 - Dec 21
8.2 out of 10, Very Good, (1000)
"Felt like home"
Janine
The price is NT$3,378
NT$4,028 total
includes taxes & fees
Jan 19 - 2026/1/20
Howard Johnson Hotel & Suites by Wyndham Oacoma
Howard Johnson Hotel & Suites by Wyndham OacomaOacoma
8.6 out of 10, Excellent, (1000)
"Very clean rooms and pool areas. Staff was very friendly, price was great. Just overall a wonderful stay"
Marin
The price is NT$2,980
NT$3,302 total
includes taxes & fees
Dec 27 - Dec 28
8.2 out of 10, Very Good, (535)
"Very nice quaint hotel"
Amber
The price is NT$2,604
NT$2,893 total
includes taxes & fees
Dec 20 - Dec 21
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Central South Dakota Hotel Reviews
AmericInn by Wyndham Chamberlain - Conference Center
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Cheap Hotels in Chamberlain
- Kimball Hotels
- Family Hotels in Chamberlain
- Hotels with an Indoor Pool in Chamberlain
- Lower Brule Hotels
- Golf Hotels in Pierre
- Hotels with Hot Tubs in Chamberlain
- Luxury Hotels in Kimball
- Pet-Friendly Hotels in Oacoma
- Villas in Presho
- Waterpark Hotels in Pierre
- Hotels near South Dakota's Original 1880 Town
- Winner Hotels
- Chamberlain Hotels
- Presho Hotels
- Fort Thompson Hotels
- Pet-Friendly Hotels in Pierre
- Beach Hotels in Winner
- Hotels with Bars in Winner
- Oacoma Hotels
- Cabin Rentals in Harrold
- Murdo Hotels
- Kennebec Hotels
- Cabin Rentals in Fort Pierre
- Pet-Friendly Hotels in Fort Pierre
- Dixon Hotels
- Cabin Rentals in Jones County
- Hotels near Oahe Dam
- Pet-Friendly Hotels in Miller
- Flights from Ho Chi Minh City (SGN) to Pierre (PIR)
- Flights from Huntsville (HSV) to Pierre (PIR)
- Flights from Grand Island (GRI) to Pierre (PIR)
- Flights from Miami (MIA) to Pierre (PIR)
- Flights from Augsburg (AGB) to Pierre (PIR)
- Flights from Tyler (TYR) to Pierre (PIR)
- Flights from Nice (NCE) to Pierre (PIR)
- Flights from McGrath (MCG) to Pierre (PIR)
- Flights from Kirksville (IRK) to Pierre (PIR)
- Flights from Houston (IAH) to Pierre (PIR)
- Flights from Bloomington (BMI) to Pierre (PIR)
- Flights from Wawa (YXZ) to Pierre (PIR)
- Flights from Shreveport (SHV) to Pierre (PIR)
- Flights from Hull (HUY) to Pierre (PIR)
- Flights from Guwahati (GAU) to Pierre (PIR)
- Flights from Butte (BTM) to Pierre (PIR)
- Flights from Rock Springs (RKS) to Pierre (PIR)
- Flights from Brussels (BRU) to Pierre (PIR)
- Flights from Cedar City (CDC) to Pierre (PIR)
- Flights from Cebu (CEB) to Pierre (PIR)
- Flights from Daytona Beach (DAB) to Pierre (PIR)
- Flights from Colorado Springs (COS) to Pierre (PIR)
- Flights from Roswell (ROW) to Pierre (PIR)
- Flights to Chamberlain
- Flights from Bangkok (BKK) to Pierre (PIR)
- Flights from Presho
- Flights from Guerrero Negro (GUB) to Pierre (PIR)
- Flights from Washington (IAD) to Pierre (PIR)
- Flights from Brainerd (BRD) to Pierre (PIR)
- Flights from Billings (BIL) to Pierre (PIR)
- Flights from New York (JFK) to Pierre (PIR)
- Flights from Rogers (ROG) to Pierre (PIR)
- Flights from Minot (MOT) to Pierre (PIR)
- Flights from Machala (MCH) to Pierre (PIR)
- Flights from Gaya (GAY) to Pierre (PIR)
- Flights from Fayetteville (FAY) to Pierre (PIR)
- Flights from Yogyakarta (JOG) to Pierre (PIR)
- Flights from Sabahat (SXS) to Pierre (PIR)
- Flights from Dublin (DUB) to Pierre (PIR)
- Flights from Buffalo (BUF) to Pierre (PIR)
- Flights from Managua (MGA) to Pierre (PIR)
- Akta Lakota Museum And Cultural Center
- Kimball Park
- Visit Fort Thompson
- Visit Chamberlain
- Visit Oacoma
- Winner Vacations
- La Framboise Island
- Visit South Dakota
- Pioneer Auto Museum
- South Dakota Tractor Museum
- Dignity Statue
- South Dakota's Original 1880 Town
- Visit Central South Dakota
- Visit Murdo
- Pierre Players
- Visit Dixon
- Visit Kennebec
- Roam Free Park
- Hertz Rental Cars in Pierre
- Car rentals near Akta Lakota Museum And Cultural Center
- Easirent Rental Cars in Kennebec
- Car rental Lower Brule
- Budget Rental Cars in Murdo
- Discount Car Rentals Rental Cars in Winner
- Ace Rental Cars in Vivian
- Car rental Fort Pierre
- Avis Rental Cars in Pierre Regional
- Car rentals near Iron Nation Recreation Area
- Drive-A-Matic Rental Cars in Pierre
- Orlando Rental Cars in Winner