A calm river with boats, lush greenery, and a clear blue sky.

Big Pine Key 5 Stars Hotels

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Check availability on Big Pine Key 5 Star Hotels

Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Big Pine Key 5-star hotels

An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.
A bar area with wooden chairs, a bar counter, and a variety of bottles and glasses.
An aerial view of a resort with a large building, a beach, and a pier in the background.
A beach with white chairs and kayaks, palm trees, and a clear view of the ocean.

1. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
Marathon
United States
Andrew
NT$5,859
NT$8,468 total
includes taxes & fees
Sep 29 - Sep 30
Isla Bella Beach Resort & Spa
A resort pool with a view of the sea, surrounded by palm trees and lounge chairs.
A wooden deck with a spiral staircase leading to an upper level.
A clean, empty garage with fluorescent lighting, a metal garage door, and visible plumbing on the ceiling.
A modern kitchen with white cabinetry, a marble island, and wooden bar stools.

2. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy Marathon FL
NT$5,818
NT$8,575 total
Oct 19 - Oct 20
includes taxes & fees
Tranquility Bay Beachfront Hotel and Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

1996 Overseas Highway Marathon FL
NT$4,661
NT$6,439 total
Oct 11 - Oct 12
includes taxes & fees
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club

58182 Overseas Hwy Marathon FL
NT$5,559
NT$7,778 total
Oct 27 - Oct 28
includes taxes & fees
Grassy Flats Resort & Beach Club
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A beach with a palm tree, clear blue water, and a bridge in the distance.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Every thing was excellent"
DARIEL 2-night trip
Posted 1 hour ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for 5-star hotels in Big Pine Key on Expedia. The amount you pay will depend on when you want to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to find the ideal high-end stay.
  • Search for the lowest price per night from NT$6,439
What makes a hotel 5 stars in Big Pine Key?
Flawless guest service characterizes every 5-star hotel in Big Pine Key. From the moment you enter the lobby, staff attend to your every whim, whether recommending activities or providing a turn-down service. Also, hotels have to offer superior conveniences to obtain a 5-star rating. These can include luxury bath products, saunas or spas, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find an upscale retreat in Big Pine Key where most of what you need is included. Next, narrow your results for properties that have 5 stars and are described as "All inclusive." The most important thing on the agenda at these stays? Pure enjoyment and indulgence.

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