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Top Luxury Southeastern Indiana Hotels

21c Museum Hotel Louisville

700 W Main Street Louisville KY

3 min walk from Louisville Slugger Museum

21c Museum Hotel Louisville is one of the Louisville luxury 4.5-star boutique properties where you can treat yourself to Champagne service, massage services, ...

9.4/10 Exceptional! (1,005 reviews)

"21c is a great location for those visiting downtown Louisville. The staff was attentive and very friendly. Love the art and fun features throughout the hotel, restaurant and bar. We will be back."

Reviewed on 2026/6/21

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

2 hours drive from Louisville Slugger Museum

Treat yourself to a luxury stay at West Baden Springs Hotel, where you can enjoy amenities like plush bedding, designer toiletries, and more. Deluxe amenities ...

The Brown Hotel

335 W Broadway Louisville KY

16 min walk from Louisville Slugger Museum

The Brown Hotel is a Louisville luxury 4.5-star boutique property where you can pamper yourself with Egyptian cotton sheets, plush bedding, and more. The restaurant, ...

9.4/10 Exceptional! (1,246 reviews)

"The hotel has been well maintained and was comfortable. The staff was friendly and helpful. The room had dim lighting. The water pressure was a bit low but did the job. We were on the 11th floor. Hotel location was great. Parking was a small walk so we did valet at $36ish per day and worked out ..."

Reviewed on 2026/6/19

See all 1,131 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.