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Top Luxury Central Iowa Hotels

Des Lux Hotel

800 Locust St Des Moines IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at Des Lux Hotel, where you can enjoy amenities like designer toiletries, flat-screen TVs, and more. Notable amenities include ...

9.6/10 Exceptional! (1,119 reviews)

"Nice!"

Reviewed on 2026/11/8

Sonesta Essential Des Moines

4755 Merle Hay Road Des Moines IA

1 hour drive from Iowa State University

Indulge yourself with upscale accommodations at Sonesta Essential Des Moines, where you'll enjoy amenities like premium channels and more.

La Quinta Inn & Suites by Wyndham Des Moines West Clive

1390 Nw 118th St Clive IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at La Quinta Inn & Suites by Wyndham Des Moines West Clive, where you can enjoy amenities like plush bedding, HDTVs, and ...

8.6/10 Excellent! (1,004 reviews)

"Air did not work the best in the room and our key to get in our room did not work for the pool. But staff was Amazing!!!"

Reviewed on 2026/11/9

See all 1,585 properties in Central Iowa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.