Plan, book, travel with confidence
Better together
Save up to NT$25,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Eastern South Dakota Hotels

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport

3101 W Russell St Sioux Falls SD

7 min drive from Sanford USD Medical Center

Be treated to luxurious accommodations at Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport, where you can enjoy amenities like hydromassage showers, ...

7/10 Good! (1,012 reviews)

"The staff was nice, breakfast was good! The he room however was not great at all. Upon entry it smelled so strong of a dog odor, I determined it was the top blanket on the beds. There was dirty areas but the bathroom was the worst. Definitely something going on up on the ceiling, though a good shower ..."

Reviewed on 2026/6/4

Econo Lodge Sioux Falls Empire Mall

3500 Gateway Boulevard Sioux Falls SD

7 min drive from Sanford USD Medical Center

Stay in the lap of luxury at Econo Lodge Sioux Falls Empire Mall, where you can enjoy amenities like premium channels, flat-screen TVs, and more.

7/10 Good! (442 reviews)

Economy hotel, no thrills, but it's nice

"Staff was really nice. Rooms are spacious. Good value and convenient to many stores/restaurants, etc. Rooms for clean."

Reviewed on 2022/10/18

My Place Hotel - Sioux Falls, SD

3005 S. Carolyn Ave Sioux Falls SD

6 min drive from Sanford USD Medical Center

Go for a luxurious stay at My Place Hotel - Sioux Falls, SD, where you can enjoy amenities like pillowtop beds, premium channels, and more.

8.4/10 Very Good! (1,012 reviews)

"Nice big room, very clean."

Reviewed on 2026/6/4

See all 954 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.