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Top Luxury Eastern South Dakota Hotels

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport

3101 W Russell St Sioux Falls SD

25 min walk from Denny Sanford Premier Center

Be treated to luxurious accommodations at Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport, where you can enjoy amenities like hydromassage showers, ...

6.6/10 (1,009 reviews)

My room was always spotless and housekeeping made sure I started off my day with fresh clean towels and wash rags

Reviewed on 2026/1/25

Econo Lodge Sioux Falls Empire Mall

3500 Gateway Boulevard Sioux Falls SD

9 min drive from Denny Sanford Premier Center

Stay in the lap of luxury at Econo Lodge Sioux Falls Empire Mall, where you can enjoy amenities like premium channels, flat-screen TVs, and more.

Economy hotel, no thrills, but it's nice

Staff was really nice. Rooms are spacious. Good value and convenient to many stores/restaurants, etc. Rooms for clean.

Reviewed on 2022/10/18

My Place Hotel - Sioux Falls, SD

3005 S. Carolyn Ave Sioux Falls SD

8 min drive from Denny Sanford Premier Center

Go for a luxurious stay at My Place Hotel - Sioux Falls, SD, where you can enjoy amenities like pillowtop beds, premium channels, and more.

8.4/10 Very Good! (1,004 reviews)

clean, comfortable, good handicap access

Reviewed on 2026/1/20

See all 952 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.