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Top Luxury Eastern South Dakota Hotels

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport

3101 W Russell St Sioux Falls SD

7 min drive from Sanford USD Medical Center

Be treated to luxurious accommodations at Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport, where you can enjoy amenities like hydromassage showers, ...

7/10 Good! (1,008 reviews)

"Reasonable price for a night. It wasn’t super clean and the restroom toilet makes running water noise throughout the night. Staffs are friendly and bed pretty comfortable."

Reviewed on 2026/6/4

Econo Lodge Sioux Falls Empire Mall

3500 Gateway Boulevard Sioux Falls SD

7 min drive from Sanford USD Medical Center

Stay in the lap of luxury at Econo Lodge Sioux Falls Empire Mall, where you can enjoy amenities like premium channels, flat-screen TVs, and more.

7/10 Good! (442 reviews)

Economy hotel, no thrills, but it's nice

"Staff was really nice. Rooms are spacious. Good value and convenient to many stores/restaurants, etc. Rooms for clean."

Reviewed on 2022/10/18

My Place Hotel - Sioux Falls, SD

3005 S. Carolyn Ave Sioux Falls SD

6 min drive from Sanford USD Medical Center

Go for a luxurious stay at My Place Hotel - Sioux Falls, SD, where you can enjoy amenities like pillowtop beds, premium channels, and more.

8.4/10 Very Good! (1,010 reviews)

"The hotel was conveniently located and check in was quick. The front desk woman was not helpful during checkout but maybe we caught her on a bad day."

Reviewed on 2026/6/3

See all 954 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.