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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,002 reviews)

Exceptional experience

Reviewed on 2026/5/1

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.8/10 Excellent! (1,010 reviews)

Everything was great. The staff was helpful room was comfortable great restaurant attached lounge bar was nice to watch the game

Reviewed on 2026/5/4

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

8/10 Very Good! (1,003 reviews)

My room was very nice. Very clean and well-kept. I made sure to compliment the housekeeping staff when I checked out. Would highly recommend.

Reviewed on 2026/5/5

See all 2,979 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.