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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,002 reviews)

Exceptional experience

Reviewed on 2026/5/1

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.8/10 Excellent! (1,007 reviews)

Very limited parking for large vehicles. Had to park ours on the city street and call parking services to coordinate for the parking. You would have thought the staff would have done that. But oh well.

Reviewed on 2026/5/3

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

8/10 Very Good! (1,002 reviews)

I stayed in room 220. The bed that was near the window, the mattress needs replacement period, you can actually feel the springs. Who ever did the remodeling you can tell did a cheap job and it shows. Would I stay at another sleep Inn probably not. Who ever owns or operates this sleep inn does not ...

Reviewed on 2026/5/3

See all 2,979 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.