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Top Luxury Florida Keys Hotels

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue Key West FL

26 min drive from Florida Keys Beaches

Pamper yourself with a luxury stay at Oceans Edge Key West Resort, Hotel & Marina, where you can enjoy amenities like Egyptian cotton sheets, plush bedding, ...

9/10 Wonderful! (1,866 reviews)

"Love the way the place looks location and price."

Reviewed on 2026/6/23

The Marker Key West Harbor Resort

200 William Street Key West FL

36 min drive from Florida Keys Beaches

Be treated to a grand stay at The Marker Key West Harbor Resort, where you'll find deep soaking bathtubs and premium bedding. The 3 outdoor pools, poolside bar, ...

9.2/10 Wonderful! (1,006 reviews)

"Great location. Room overlooking the harbor was great, as spent mornings and evenings on balcony watching all the activities."

Reviewed on 2026/6/22

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Cheeca Lodge & Spa is a Islamorada luxury 5-star beach property where you can treat yourself to Champagne service, massage services, and more. The 2 poolside ...

9.2/10 Wonderful! (1,329 reviews)

"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."

Reviewed on 2026/6/23

See all 8,301 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.