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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.

9.2/10 Wonderful! (1,387 reviews)

Why leave the Madonna Inn when you can do it all there. No, but really! It has everything!!!! The town of SLO is cute too, but wow this place really has it all! Live music, spa, pool, cafe/bakery, restaurant, garden, horse trail riding… & more. All the rooms are unique and the staff is very friendly. ...

Reviewed on 2026/3/19

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...

9/10 Wonderful! (1,196 reviews)

Good location. Typical

Reviewed on 2026/3/14

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.

9.6/10 Exceptional! (1,000 reviews)

Loved my experience and the location. My room was perfect, enjoyed the hot tub and proximity to the beach. Also, was felt extra spoiled by all the extra goodies the staff wouldn’t stop giving us…will be back!!

Reviewed on 2026/3/14

See all 1,863 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.