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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,407 reviews)

"Always enjoy my stay at the Kahler Grand! You can’t get a better location for Mayo Clinic appointments, shopping, terrific restaurants and friendly staff."

Reviewed on 2026/11/9

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more.

7.8/10 Good! (523 reviews)

"Clean room, stayed two nights & housekeeping came in while we were out, made the bed and gave us clean towels. They accommodated our request for first floor room. We’ve stayed here several times, always pleasant staff & accommodating"

Reviewed on 2026/11/8

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

See all 1,247 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.