Photo by Kirsten

Plan, book, travel with confidence
Better together
Save up to NT$25,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,026 reviews)

Was put in a room that is used for Expedia customers. Only 2 smaller windows, one foged up. Not a good mattress. 2 outside doors, on both side of our room. Slammed night and day. Rattled our room. Plan on better room next time.

Reviewed on 2026/4/27

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more. Deluxe amenities ...

7.8/10 Good! (471 reviews)

Breakfast was great! Coffee didn't taste fresh, but we got there at 9ish, so maybe just old. But sometimes it can be dirty pots. Other than that, it was a fine place to stay for the night. I did wake up a little congested, after having left the fan on all night. Upon inspecting it, the filter was ...

Reviewed on 2026/4/21

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

7.8/10 Good! (1,004 reviews)

Pool is wonderful with play stuff for kids and a great hot tub. The breakfast area is the cleanest ever! There is no meat for breakfast but otherwise anything you'd need. Great job there! The property is attached to Famous Dave's BBQ and it is GREAT! The property is old but clean. If you had to, ...

Reviewed on 2026/4/27

See all 1,208 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.