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Top Luxury Western Illinois Hotels

Econo Lodge Quincy

224 N 36th Street Quincy IL

4 hours drive from OSF Saint Francis Medical Center

Pamper yourself with a luxe vacation at Econo Lodge Quincy.

6.8/10 (1,005 reviews)

"The name changed without notification. Econ lodge does not exist. The hotel in place of it is under renovation and there are boxes and stuff everywhere. No cleaning came in or out during a 5 days stay"

Reviewed on 2026/7/14

Baymont by Wyndham Peoria

2002 West War Memorial Drive Peoria IL

8 min drive from OSF Saint Francis Medical Center

Treat yourself to upscale accommodations at Baymont by Wyndham Peoria, where you'll enjoy amenities like premium channels and more. Sought-after amenities include ...

6.6/10 (549 reviews)

"The hotel is nice, And they have very good attention to their customers"

Reviewed on 2026/7/10

Mark Twain Hotel

225 NE Adams Street Peoria IL

14 min walk from OSF Saint Francis Medical Center

Treat yourself to a luxury stay at Mark Twain Hotel, where you can enjoy amenities like premium channels, flat-screen TVs, and more.

See all 676 properties in Western Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.