Photo by Visit Greenville, South Carolina

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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.2/10 Wonderful! (1,003 reviews)

Easy check in and rooms were clean. The hotel has an old charm to it and is in a great location.

Reviewed on 2025/11/24

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.6/10 Excellent! (1,004 reviews)

They did a wonderful job everything was great!!!

Reviewed on 2025/11/24

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

7.8/10 Good! (1,009 reviews)

Location was very convenient for me. Hotel was quiet. I would stay here again!

Reviewed on 2025/11/28

See all 2,897 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.