Upstate South Carolina Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to NT$25,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Top Luxury Upstate South Carolina Hotels
The Westin Poinsett Greenville
120 South Main St Greenville SC
- 1 hour drive from Clemson University
Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...
Hyatt Regency Greenville
220 N Main St Greenville SC
- 1 hour drive from Clemson University
Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...
8.8/10 Excellent! (1,008 reviews)
"All good"
Reviewed on 2026/8/7
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr Greenville SC
- 1 hour drive from Clemson University
Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
