Upstate South Carolina Luxury Vacations 2026

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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (1,007 reviews)

"Best location on the city"

Reviewed on 2026/8/22

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...

8.6/10 Excellent! (1,010 reviews)

"Our first room had a bathroom faucet that was broken and they were not able to repair it. They moved us to another room and the new room was what I would call an "architectural afterthought" .. It was a fairly small room in a very odd size/configuration due to the shape of the hotel around it. It ..."

Reviewed on 2026/8/23

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.

See all 3,052 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.