Upstate South Carolina Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to NT$25,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury Upstate South Carolina Hotels
The Westin Poinsett Greenville
120 South Main St Greenville SC
- 1 hour drive from Clemson University
Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...
9.4/10 Exceptional! (1,007 reviews)
"Best location on the city"
Reviewed on 2026/8/22
Hyatt Regency Greenville
220 N Main St Greenville SC
- 1 hour drive from Clemson University
Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...
8.6/10 Excellent! (1,008 reviews)
"During both check in and check out we had lost luggage and valet related issues. During check in, our bags were misplaced and during check out their valet after the 6am start time, no one was in attendance to retrieve our car, making us late for a meeting."
Reviewed on 2026/8/22
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr Greenville SC
- 1 hour drive from Clemson University
Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
