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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.

9.2/10 Wonderful! (1,319 reviews)

We love this place!

Reviewed on 2025/12/5

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...

9/10 Wonderful! (1,134 reviews)

Clean and the staff was awesome and reservation folks were very helpful

Reviewed on 2025/11/19

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.

9.4/10 Exceptional! (1,000 reviews)

Incredible place. Will definitely come back.

Reviewed on 2025/11/21

See all 1,861 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.