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Top Adults Only Charleston Hotels

86 Cannon Charleston - Adults Only

86 Cannon Street Charleston SC

5 min walk from Medical University of South Carolina

Book a stay at this luxury inn in Charleston. Enjoy free breakfast, free WiFi, and free bicycles on site. Popular attractions Charleston City Market and South ...

The Jasmine House

64 Hassell Street Charleston SC

7 min walk from Medical University of South Carolina

Stay at this guesthouse in Charleston. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular ...

9.4/10 Exceptional! (385 reviews)

Our original room we booked had an issue so they changed our room unfortunately but wavered the parking fee. The inn is in a great location within walking distance to king street. The room has a wonderful basket full of goodies and drinks in the mini fridge that was complimentary which was wonderful! ...

Reviewed on 2026/5/7

Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

5757 Palm Boulevard Isle of Palms SC

7 min drive from Medical University of South Carolina

Book a stay at this beach resort in Isle of Palms. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (1,005 reviews)

Nice property with lots of amenities.

Reviewed on 2026/4/30

See all 5,043 properties in Charleston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.