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Top Adults Only Islamorada Hotels

Casa Morada

136 Madeira Road Islamorada FL

22 min drive from Anne's Beach

Book a stay at this beach hotel in Islamorada. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9.4/10 Exceptional! (420 reviews)

The room was excellent

Reviewed on 2026/1/21

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

21 min drive from Anne's Beach

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9.2/10 Wonderful! (1,300 reviews)

This palce is awesome. Clean rooms. 2 large pools with a view. Covered garage spot.

Reviewed on 2026/1/22

See all 2,224 properties in Islamorada

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.