Find Resorts & Hotels with Spas in St. Charles Historic District, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on St. Charles Historic District Resorts & Hotels with Spas

Next weekend
In two weeks

Our top choices for St. Charles Historic District hotels with a spa

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1508)
"Hotel was comfortable, clean and unique. All staff was wonderful "
United States
Sharon
The price is NT$4,232
NT$5,107 total
includes taxes & fees
Dec 29 - Dec 30
21C Museum Hotel St Louis

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1007)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is NT$4,802
NT$6,136 total
includes taxes & fees
Dec 22 - Dec 23
Ameristar Casino Resort and Spa

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is NT$15,749
NT$18,386 total
includes taxes & fees
Dec 22 - Dec 23
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top St. Charles Historic District Hotel Reviews

Frequently asked questions

Looking for a spa hotel in St. Charles Historic District?
Forget the stress of everyday life and book yourself a lush spa hotel. Travelers like St. Charles Historic District for the popular shops and historical sites. Enjoy the live music and riverfront during your vacation. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your weekend away.
What's there to see and do in St. Charles Historic District?
Enjoy St. Charles Historic District with a stop at Historic Main Street, Missouri River, and First Missouri State Capitol Historic Site. If you have a bit of extra time while you're in the area, you might want to check out Lewis & Clark Boathouse and Nature Center and Missouri Artists on Main.
What is a St. Charles Historic District spa hotel?
Spa hotels in St. Charles Historic District provide lodging and have an on-site spa offering services such as couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia