Find Luxury Hotels in St. Ann, MO

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Our top choices for St. Ann luxury hotels

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1001)
"Everything exceeded my expectations from the welcoming staff to the luxuriously appointed room, to the 4 feet deep bathtub in which to soak my cares away--it was a total dream come true. I would come back in a heartbeat at this home away from home. "
United States
Lynne
The price is NT$13,045
NT$15,254 total
includes taxes & fees
Jan 2 - 2026/1/3
Four Seasons Hotel St Louis

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (554)
"The stay was ok even though nothing was explained to be. The hours of restaurant, where the gym is located about the bar in the room nothing. "
United States
Shemelle
The price is NT$15,686
NT$18,311 total
includes taxes & fees
Jan 1 - 2026/1/2
The Ritz-Carlton, St. Louis

Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1105)
"Clean room, great restaurant and bar down stairs "
United States
Ambria
The price is NT$4,684
NT$5,570 total
includes taxes & fees
Jan 1 - 2026/1/2
Live by Loews - St.Louis

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis
8.4 out of 10, Very Good, (4041)
"Staff was supper nice and it all went so smooth."
United States
Brayden
The price is NT$4,055
NT$4,782 total
includes taxes & fees
Jan 1 - 2026/1/2
Hyatt Regency St. Louis at The Arch

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1010)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is NT$5,630
NT$7,102 total
includes taxes & fees
Jan 11 - 2026/1/12
Ameristar Casino Resort and Spa

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (470)
"Great hotel. "
United States
Abby
The price is NT$4,872
NT$5,795 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Saint Louis, Autograph Collection

Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1921)
"Great place"
United States
Edward
The price is NT$3,911
NT$4,651 total
includes taxes & fees
Jan 12 - 2026/1/13
Moonrise Hotel

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (681)
"The gym was amazing! "
United States
Hannah
The price is NT$3,747
NT$4,412 total
includes taxes & fees
Jan 1 - 2026/1/2
Le Méridien St. Louis Clayton

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1515)
"Hotel was comfortable, clean and unique. All staff was wonderful "
United States
Sharon
The price is NT$4,498
NT$5,417 total
includes taxes & fees
Jan 5 - 2026/1/6
21C Museum Hotel St Louis

St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
4.0 star property
Downtown West
8.6 out of 10, Excellent, (1005)
"The hotel itself was just beautiful and grand! Beautifully decorated for the holidays and the amenities and attractions surrounding Union station were perfect for our family of 4! Our room was spacious and clean and we loved our stay! "
United States
Kelly
The price is NT$4,923
NT$5,855 total
includes taxes & fees
Jan 15 - 2026/1/16
St. Louis Union Station Hotel, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top St. Ann Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to St. Ann?
Let Expedia help you arrange your flight to St. Louis Lambert Intl. Airport (STL) airport or St. Louis, MO (SUS-Spirit of St. Louis) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that St. Ann offers. During your visit, you might want to enjoy the restaurants and bars which St. Ann is known for.
When can I expect good weather in St. Ann?
Planning for the weather is an important factor for making your trip to St. Ann a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for St. Ann is 50 inches.
What's there to see and do in St. Ann?
When you're in St. Ann, enjoy exploring the sights and attractions here including St. Louis Union Station, Busch Stadium, and Westport Plaza. If you have a bit of extra time while you're in the area, you might want to check out Hollywood Casino Amphitheatre and Blanche M. Touhill Performing Arts Center.

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